Results 51 to 60 of about 44,821 (231)

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source

HIV-1 efficient entry in inner foreskin is mediated by elevated CCL5/RANTES that recruits T cells and fuels conjugate formation with Langerhans cells. [PDF]

PLoS Pathogens, 2011
Male circumcision reduces acquisition of HIV-1 by 60%. Hence, the foreskin is an HIV-1 entry portal during sexual transmission. We recently reported that efficient HIV-1 transmission occurs following 1 h of polarized exposure of the inner, but not outer,
Zhicheng Zhou, Nicolas Barry de Longchamps, Alain Schmitt, Marc Zerbib, Marie-Cécile Vacher-Lavenu, Morgane Bomsel, Yonatan Ganor   +6 more
doaj   +1 more source

Amplification of simian retroviral sequences from human recipients of baboon liver transplants [PDF]

, 1998
Investigations into the use of baboons as organ donors for human transplant recipients, a procedure called xenotransplantation, have raised the specter of transmitting baboon viruses to humans and possibly establishing new human infectious diseases ...
Anonymous, ANTHONY G. COMUZZIE, EVELYN M. WHITEHEAD, JONATHAN S. ALLAN, KAREN L. LEIGHTON, M. MICHELLE LELAND, MARIAN G. MICHAELS, ROBERT E. LANFORD, SUZANNE R. BROUSSARD, THOMAS E. STARZL, van der Kuyl AC, WALID HENEINE, WILLIAM M. SWITZER   +12 more
core   +1 more source

CD207‐Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan, Yunhui Wu, Feng Liu, Heng Fu, Yaqi Meng, Yingwei Ou, Xijing Yuan, Ian M. Adcock, Man Jia, Xiaoning Zeng, Xin Yao   +10 more
wiley   +1 more source

Circumcision and prevention of HIV and AIDS in Zimbabwe: Male genital cutting as a religio-cultural rite

HTS Teologiese Studies/Theological Studies, 2018
Circumcision originated from ancient religious (biblical) and cultural societies. Study has shown that in both the biblical (Israelite) context and among the Karanga people in Zimbabwe circumcision emerged as a rite of passage for a boy child’s entry ...
Temba T. Rugwiji
doaj   +1 more source

Decoding the Cellular Heterogeneity and Malignant Progression of Human Penile Squamous Cell Carcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
Single‐cell transcriptomic and functional analyses identify SEMA3C as a key regulator of tumor progression and tumor microenvironment remodeling in penile squamous cell carcinoma. SEMA3C promotes epithelial–mesenchymal transition, tumor growth, and invasion while shaping an immunosuppressive microenvironment, highlighting its potential as a prognostic ...
Xiheng Hu, Wensheng Shi, Liang Dong, Lingjuan Huang, Xiyuan Zhang, Yiting Feng, Jie Sun, Lanlan Liu, Teng Liu, Jun Fu, Bowen Zhong, Qihao Leng, Xiaohua Wu, Minfeng Chen, Lingfang Li, Yuan Li, Xin Jin, Long Wang, Jian Cao, Xin Li, Mingzhu Yin, Xiang Chen   +21 more
wiley   +1 more source

HSV-2 Infection of Human Genital Epithelial Cells Upregulates TLR9 Expression Through the SP1/JNK Signaling Pathway [PDF]

, 2020
It is known that herpes simplex virus type 2 (HSV-2) triggers the activation of Toll-like receptor (TLR) 9 signaling pathway and the consequent production of antiviral cytokines in dendritic cells.
Barreto, M, Chowdhury, T, Fu, M, Guan, X, Hu, K, Hu, Q, Li, M, Luo, S, Singh, R, Wang, J, Xiao, J, Zhang, M   +11 more
core   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Histological and morphological development of the prepuce from birth to prepubertal age [PDF]

Investigative and Clinical Urology
Purpose: To study the histological changes of the preputial tissue from birth to prepubertal age in order to define unnoticed morphological changes. Materials and Methods: Prepuce samples were obtained from 79 healthy boys who underwent routine ritual ...
Erim Erdem, Mustafa Kaplan Caliskan, Meryem Ilkay Karagul , Erdem Akbay, Banu Coskun Yilmaz, Yuksel Cem Aygun   +5 more
doaj   +1 more source

Attitude towards donation of the excised foreskin after circumcision surgery for research: A study from Madinah, Saudi Arabia.

PLoS ONE, 2023
Studies have shown the possibility of using the part of the foreskin removed after circumcision in the field of scientific and therapeutic research. Donations of tissues and organs are always associated with ethical challenges posed by bioethicists and ...
Omar F Khabour, Waleed H Mahallawi, Aiman I Ali, Hamdi H Almaramhy, Abdulaziz M Bakhsh, Ahmed Abu-Siniyeh   +5 more
doaj   +1 more source