Results 111 to 120 of about 43,730 (298)

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

The conservation of saproxylic beetles in boreal forest [PDF]

, 2006
Forest management has altered the age structure, tree species composition and dead wood availability of Swedish boreal forests. As a consequence, many saproxylic (wood living) insect species have decreased in abundance and many species are threatened ...
Johansson, Therese
core  

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Reforestation-induced changes of landscape composition and configuration modulate freshwater supply and flooding risk of tropical watersheds.

PLoS ONE, 2017
Impact of changes in land cover and land use on hydrological service of tropical watersheds is one of the focal research tropics in both hydrology and Land Cover Land Use Changes (LCLUC).
Qiong Gao, Mei Yu
doaj   +1 more source

Echolocation and Stratum Preference: Key Trait Correlates of Vulnerability of Insectivorous Bats to Tropical Forest Fragmentation

Frontiers in Ecology and Evolution, 2019
Habitat loss and fragmentation rank high amongst the most pressing threats to biodiversity. Understanding how variation in functional traits is associated with species vulnerability in fragmented landscapes is central to the design of effective ...
Silvia Fraixedas Núñez, Adrià López-Baucells, Adrià López-Baucells, Adrià López-Baucells, Ricardo Rocha, Ricardo Rocha, Ricardo Rocha, Fábio Z. Farneda, Fábio Z. Farneda, Fábio Z. Farneda, Paulo E. D. Bobrowiec, Jorge M. Palmeirim, Christoph F. J. Meyer, Christoph F. J. Meyer, Christoph F. J. Meyer   +14 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Does forest loss and fragmentation reduce woodpecker-associated ecosystem functions?

Global Ecology and Conservation
Around the world, land-use change caused by human-activity threatens biodiversity, which often results in forest loss and fragmentation, and the loss of forest biodiversity.
Kazuma Yasuda, Daiki Kato, Shoji Naoe, Tatsuya Amano, Tetsuro Yoshikawa, Kahoko Tochigi, Shinsuke Koike   +6 more
doaj   +1 more source

Data‐Driven Modeling of Composition–Processing–Microstructure Relations for Recycled Aluminum Cast Alloys

Advanced Science, EarlyView.
Interpretable machine learning reveals how composition and processing govern the formation and microstructural burden of Fe‐rich intermetallic compounds in recycled Al–Si–Fe–Mn alloys. By separating morphology selection from morphology‐conditioned burden partitioning, this framework shows that identical Fe contents can yield different intermetallic ...
Jaemin Wang, Waleed Mohammed, Dierk Raabe   +2 more
wiley   +1 more source

Multi-scale analysis reveals the differential impacts of forest loss and fragmentation on mammal species in Southwest China and their conservation implications

Global Ecology and Conservation
Global land-use changes have driven forest loss and fragmentation, resulting in a drastic decline in biodiversity levels. Understanding how biological communities respond to anthropogenic landscapes is crucial for developing optimal spatial strategies ...
Jipeng Tian, Haijun Su
doaj   +1 more source

Physics‐Informed Machine Learning for Sustainable Alloy Design: Toward a Recyclable Unified Q&P Steel

Advanced Science, EarlyView.
A physics‐informed property‐bridging framework links high‐throughput hardness screening to tensile performance in quenching and partitioning steels. By transferring metallurgically guided representations across properties, a single alloy composition is designed to achieve multiple strength grades through heat‐treatment tuning alone, offering a ...
Xiaolu Wei, Yong Li, Chenchong Wang, Lingyu Wang, Xiang Song, Keming Mao, Yu Zhang, Wei Xu   +7 more
wiley   +1 more source