Results 161 to 170 of about 400,552 (303)

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Polyester Resin-Quartz Composites in the Age of Artificial Intelligence and Digital Twins: Current Advances, Future Perspectives and an Application Example. [PDF]

Polymers (Basel)
Suess M, Kurzweil P.
europepmc   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Nonlinear Interactions and Spatial Heterogeneity of Ecosystem Service Transitions in an Ecologically Fragile Karst Region of Southwest China. [PDF]

Ecol Evol
Wu Y, Yang J, Li S, Mu Y, Marod D, Guo C, Yang X, Feng H, Wu R, Wu H, Yuan P, Feng S, Li S, Xing X, Luo G.   +14 more
europepmc   +1 more source

In-line measurement of wood surface roughness [PDF]

, 2020
Chuchała, Daniel, Orłowski, Kazimierz A., Sandak, Anna Malgorzata, Sandak, Jakub Michal, Taube, Piotr   +4 more
core   +1 more source

An Integrated NLP‐ML Framework for Property Prediction and Design of Steels

Advanced Science, EarlyView.
This study presents a data‐driven framework that uses language‐processing techniques to interpret steel processing descriptions and machine‐learning models to predict mechanical properties. By organising complex process histories into meaningful groups and enabling rapid property forecasts, the work supports faster, more informed steel design through ...
Kiran Devraju, Adithya Umanath Rai, Jose Thomson, Marzie Ghorbani, Shujing Zhao, Nick Birbilis   +5 more
wiley   +1 more source

Study on the influencing factors of forest-based health and wellness services from the supply and demand perspective. [PDF]

Front Public Health
Wei K, Zhou G, Zhou X, Zhang Y, Liao Q.
europepmc   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Explainable AI-Driven Quality and Condition Monitoring in Smart Manufacturing. [PDF]

Sensors (Basel)
Ahangar MN, Farhat ZA, Sivanathan A, Ketheesram N, Kaur S.   +4 more
europepmc   +1 more source

Woodland Wealth Appraisal for the East of England - Report to the Forestry Commission (East of England Conservancy) and East of England Development Agency [PDF]

, 2003
Powell, John R, Selman, Paul
core