Results 41 to 50 of about 907,535 (313)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Transcriptome dynamics of rooting zone and aboveground parts of cuttings during adventitious root formation in Cryptomeria japonica D. Don

BMC Plant Biology, 2018
Background Adventitious root formation is an essential physiological process for successful propagation of cuttings in various plant species. Because coniferous species are highly heterozygous, propagation of cuttings is of great practical use in ...
Yuki Fukuda, Tomonori Hirao, Kentaro Mishima, Mineko Ohira, Yuichiro Hiraoka, Makoto Takahashi, Atsushi Watanabe   +6 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Need for Perform ance Criteria in Evaluating the Durability of W ood Products

Forestist, 2008
Data generated İroni vvood-product durability evaluatioııs can be difficult to interpret. Standard metlıods used to evaluate the potential loııg-term durability of vvood products often provide little guidance on interpretation of test results ...
Stan Lebow, Bessie Woodward, Patricia Lebow, Carol Clausen   +3 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Bending performance of sugi cross-laminated timber (CLT) composed of different thickness laminae

Journal of Wood Science
This study aims to examine the influence of lamina thickness on the bending performance of sugi cross-laminated timber (CLT). The lamina specimens measuring 20 mm, 30 mm and 40 mm thick × 115 mm wide, and the CLT specimens composed of 5-layer–5-ply of ...
Miyuki Nakagawa, Yasushi Hiramatsu, Kenta Shindo, Fumiaki Ohki, Atsushi Miyatake   +4 more
doaj   +1 more source

Grease, Oxygen, and Air Barrier Properties of Cellulose-Coated Copy Paper

Polysaccharides
Cellulose nanomaterials have been demonstrated to be excellent barriers against grease, oxygen, and other vapors, but their implementation in packaging materials is challenging because of numerous technical and practical challenges.
Ronald Sabo, Cody Schilling, Craig Clemons, Daniel Franke, Neil R. Gribbins, Michael Landry, Kimberly Hoxie, Peter Kitin   +7 more
doaj   +1 more source

Forest product markets, forests and poverty reduction [PDF]

International Forestry Review, 2005
There is a new and increasing emphasis on poverty alleviation and livelihoods improvement in forestry, representing both a challenge and an opportunity. This paper briefly reviews the evolution of the ‘livelihoods' issue, analyzes the concept of ‘poverty alleviation' and discusses means by which forestry can contribute to livelihoods improvement.
openaire   +4 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source