Results 241 to 250 of about 154,921 (294)

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Genetically distinct hantaviruses in two bat species in Panamá. [PDF]

iScience
Yamada K, Kikuchi F, Dunnum JL, Gutiérrez-Moreno P, González D PE, Armién B, Pérez-Callejas M, Land D, Colella JP, Mizutani T, Maeda K, Suzuki M, Greiman SE, Carrión-Bonilla CA, Cook JA, Yanagihara R, Arai S.   +16 more
europepmc   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Sequential miRNA-mRNA profiling of regulatory pathways during in vitro maturation of canine oocytes. [PDF]

Anim Reprod
De Los Reyes M, Dettleff P, Palomino J, Peralta OA, Parraguez VH, Orellana B, Avendaño JM.   +6 more
europepmc   +1 more source

Corrigendum: Essential Oils prime epigenetic and metabolomic changes in tomato defense against Fusarium oxysporum. [PDF]

Front Plant Sci
Soudani S, Poza-Carrión C, De la Cruz Gómez N, González-Coloma A, Andrés MF, Berrocal-Lobo M.   +5 more
europepmc   +1 more source

Reptarenaviruses in Wild- and Captive-Origin Boid and Pythonid Snakes in Peru. [PDF]

Animals (Basel)
Otero Soberon JA, Tillis SB, Otero Corbetto JA, Gulman M, Vasquez J, Ossiboff RJ.   +5 more
europepmc   +1 more source

Prevalence and antimicrobial resistance of <i>Escherichia coli</i> in a Tertiary-level hospital. [PDF]

J Prev Med Hyg
Valenzuela-Ramirez GG, Ahumada-Santos YP, Báez-Flores ME, Beltrán-Fernandez S, Díaz-Camacho SP, Hernández-Guevara E, Morales-Morales D, Canseco-González D, Parra-Unda JR.   +8 more
europepmc   +1 more source

Shifts in trait diversity across the range of an endemic treeline species in central Chile. [PDF]

Ann Bot
Hernández C, Venegas-González A, Santini L, Craven D.   +3 more
europepmc   +1 more source

Whole Genome Characterization of Klebsiella Strains in European Hedgehogs and Human Nosocomial Settings Identified Shared Sequence Types, Antimicrobial Resistance Genes and Plasmids. [PDF]

Zoonoses Public Health
Garcias B, Seminati C, Kobras CM, Sheppard SK, Molina-López RA, Darwich L.   +5 more
europepmc   +1 more source

On the Economics of Forests

International Economic Review, 1983
Publisher Summary This chapter describes a productive process involving the point input of labour, the repeated input of land, and the point output of forest products and then describes the process in a model of the economy as a whole. The optimal duration or maturity of the process is to be determined in terms of the parameters of the model.
Kemp, Murray C, Long, Ngo Van
openaire   +1 more source