We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
The Tropical managed Forests Observatory: a research network addressing the future of tropical logged forests [PDF]
While attention to logging in the tropics has been increasing, studies on the long-term effects of silviculture on forest dynamics and ecology remain scare and spatially limited.
Sist, Plinio
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Tumor mutational burden as a determinant of metastatic dissemination patterns
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Ongoing study on the integration of biodiversity concerns in management of forest concessions in Central Africa [PDF]
Central Africa is home to the world's second largest contiguous tropical rainforest, after Amazon. Depending on countries in the sub-region, between 10% to 15% (Nasi, Cassagne, Billand, 2006) of the forests' surface area is occupied by protected areas ...
Billand, Alain +3 more
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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Are we using the most appropriate methodologies to assess the sensitivity of rainforest biodiversity to habitat disturbance? [PDF]
Accurately assessing how biodiversity responds in the Anthropocene is vital. To do so, a number of indicator taxa are commonly used to monitor human-impacted forests and the subsequent recovery of their biodiversity.
Braunholtz, L. +3 more
core +1 more source
Design, manufacturing and preliminary evaluation of a wheeltrimmer [PDF]
Control of weed is one of the most important problems in the botanic gardens, tree nurseries and plant research centers which generally are man made with high cost and time investment. In this investigation a wheel trimmer (brush cutter) was designed and
Farshid Merrikh +3 more
doaj
The heat stress for workers employed in a dairy farm
The Italian dairy production is characterized by high heterogeneity. The typology quantitatively more important (80% of national production) is represented by cow’s milk cheeses (Grana Padano cheese, string cheese, Parmesan cheese, etc.), while the ...
Alvaro Marucci +5 more
doaj +1 more source
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
The importance of forest and trees for ecosystem-based adaptation in rural landscapes [PDF]
Ecosystems provide important services that can help people adapt to climate variability and change. Scientific literature provides evidence that EBA with forests and trees can reduce social vulnerability to climate hazards; however, uncertainties and ...
Locatelli, Bruno
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