Results 21 to 30 of about 10,457 (227)
Testing exchangeability: Fork-convexity, supermartingales and e-processes [PDF]
, 2022 Suppose we observe an infinite series of coin flips X1, X2 , and wish to sequentially test the null that these binary random variables are exchangeable.
Larsson, Martin +7 more
core +1 more source
A game of substrates: replication fork remodeling and its roles in genome stability and chemo-resistance [PDF]
, 2017 During the hours that human cells spend in the DNA synthesis (S) phase of the cell cycle, they may encounter adversities such as DNA damage or shortage of nucleotides.
Julia Sidorova
core +1 more source
Flat Committed Join in Join [PDF]
, 2003 Committed Join (cJoin) is an extension of Join with high-level primitives for programming dynamic nested negotiations with compensations. In this paper we show that flat cJoin processes (i.e.
Roberto Bruni +7 more
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Replication Fork Uncoupling Causes Nascent Strand Degradation and Fork Reversal [PDF]
, 2023 Genotoxic agents can cause nascent strand degradation (NSD) and fork reversal during DNA replication. NSD and fork reversal are crucial biochemical mechanisms that maintain genome stability and they are frequently exploited by chemotherapeutic approaches.
Kavlashvili, Tamar
core
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Trouble with Diversity: Fork-Join Networks with Heterogenous Customer Population [PDF]
, 1992 Consider a feedforward network of single-server stations populated by multiple job types. Each job requires the completion of a number of tasks whose order of execution is determined by a set of deterministic precedence constraints.
Vien Nguyen, Nguyen, Viên
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source