Results 61 to 70 of about 567,732 (267)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

THE GENESIS OF PARLIAMENTARISM WITHIN A MONARCHICAL FORM OF GOVERNMENT

Russian Studies in Law and Politics
Background. The question of the development of parliamentarism in Europe and Russia at the turn of the 19th and 20th centuries remains relevant in the context of studying the political modernization of countries and searching for historical parallels ...
Svetlana A. Ryabkova, Ilya E. Kotov
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Russian pre-revolutionary scientists on the Constitutional monarchical form of Government in Russia

Известия высших учебных заведений. Поволжский регион: Общественные науки
Background. Relevance of the chosen topic is conditioned mainly due to the increased interest of society and scientists to Russian history in general and to the history of Russian law in particular.
Yu.L. Shul'zhenko
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

An opinon in favour of parliamentary Republic [PDF]

Anali Pravnog Fakulteta u Beogradu
The author puts forward the idea to replace the existing, ill-functioning semi-presidential form of government in Serbia with parliamentary government.
Popović Dragoljub
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An Assessment of Public Opinion in Balochistan about Federal Form of Government in Pakistan

Journal of Business and Social Review in Emerging Economies, 2020
Almost every state or society particularly a pluralistic one is composed of various nationalities or sub-national groups whereas every segment has its own distinct identity being a source of pride and strength for its survival.
Abdul Basit Khan, Ali Shan Shah, Tariq Aziz, Mian Muhammad Azhar   +3 more
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Review of experience of major reform of railways of the world

Nauka ta progres transportu, 2013
Purpose. To evaluate the possibility of the foreign countries experience in the reforming of railway transport of Ukraine. Methodology. On the basis of comparative analysis the suitability of foreign experience of infrastructure branches reformation ...
L.V.Martsenyuk
doaj