Results 51 to 60 of about 1,410,372 (216)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
«Soft Power» as a Form of Indirect Application of «National Interest»
Vestnik RUDN. International Relations, 2012 The article provides the information on American «soft power» that promotes U.S. national interests worldwide. There is an analysis of the evolution of «national interest» and new forms of U.S. influence on the world order.
G Yu Filimonov, S A Tsaturyan
doaj
Closed-Form Performance Analysis of the Inverse Power Lomax Fading Channel Model
MathematicsThis research presents a closed-form mathematical framework for assessing the performance of a wireless communication system in the presence of multipath fading channels with an instantaneous signal-to-noise ratio (SNR) subjected to the inverse power ...
Aleksey S. Gvozdarev
doaj +1 more source
E3S Web of Conferences, 2018 A randomized algorithm for computing the invariant zeros of the electric energy system as a dynamical system with many inputs and many outputs (MIMO system), specified in the descriptor form, is proposed. Definitions of invariant zeros are carried out by
Gadzhiev Magomed +3 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Overall Framework and Function Design of Quantified Gaming Method for New Power System Forms
Zhongguo dianliThe research on the form gaming of new power system is essential for advanced judgment of China's energy and power development, and significant for overall layout of all elements of source-network-load-storage.
Jian LI +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source