Results 141 to 150 of about 1,076 (248)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

On the use of stress-based forming limit curve for forming and fracture

, 2008
The forming limit curve (FLC) or diagram illustrates the major and minor strains expected on the surface of a deforming sheet material at the onset of local necking.
Yoon, Jeong Whan, Dick, RE, Barlat, F, Hong, SH   +3 more
core  

Small punch testing and scanning electron microscopy analysis of damage evolution in dual-phase steel. [PDF]

Sci Rep
Alsharif A, Moinuddin SQ, Pinna C.
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Evaluation of load control end-feed in hydroforming of pre-bent DP600 steel tube using the extended stress-based forming limit curve (XSFLC) failure criterion

, 2006
The work presented in this paper utilizes advanced finite element models of the pre-bending and hydroforming processes to investigate the effect of load control end-feed (EF) on the formability of DP600 steel tube in hydroforming.
Worswick, Michael J., Bardelcik, Alexander   +1 more
core  

Characterisation and modelling of ductile fracture in incremental sheet forming of an aluminium alloy with consideration of temperature variations. [PDF]

Int J Mater Form
Qin Z, Gatea S, Ou H.
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Process Design of Vinyl-Coated Metal Sheet Stamping for Prevention of Delamination and Wrinkling by DNN-Based Multi-Objective Optimization. [PDF]

Materials (Basel)
Kim MG, Ryu JC, Lee CJ, Jang JS, Ko DC.
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Formability Limits in Square Tubes and L-Section Profiles. [PDF]

Materials (Basel)
Almeida IM, Magrinho JPG, Silva MB.
europepmc   +1 more source