Results 81 to 90 of about 381,202 (261)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A Web Page Clustering Method Based on Formal Concept Analysis

Information, 2018
Web page clustering is an important technology for sorting network resources. By extraction and clustering based on the similarity of the Web page, a large amount of information on a Web page can be organized effectively.
Zuping Zhang, Jing Zhao, Xiping Yan
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Veri Tabanlarında Bilgi Keşfine Formel Bir Yaklaşım: Kısım 1 - Eşleştirme Sorguları ve Algoritmalar / A Formal Approach to Discovery in Very Large Databases: Part 1 - Association Queries and Algorithms

Bilgi Dünyası, 2002
In the last two decades, we have witnessed an explosive growth in our capabilities to both collect and store data, and generate even more data by further computer processing.
Hayri Sever, Buket Oğuz
doaj  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Use of Concept Lattices for Data Tables with Different Types of Attributes

Journal of Information and Organizational Sciences, 2012
In this paper we describe the application of Formal Concept Analysis (FCA) for analysis of data tables with different types of attributes. FCA represents one of the conceptual data mining methods.
Peter Butka, Jozef Pocs, Jana Pocsova
doaj  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Veri Tabanlarında Bilgi Keşfine Formel Bir Yaklaşım: Kısım 2 - Eşleştirme Sorguları ve Algoritmalar / A Formal Approach to Discovery in Very Large Databases: Part 2 - Association Queries and Algorithms

Bilgi Dünyası, 2003
In this study we utilize formal concept analysis to model association rules. Formal concept analysis provides a topological structure for a universe of objects and attributes.
Hayri Sever, Buket Oğuz
doaj  

A Taxonomy of the Greimas Square

Axioms
In this article I introduce the semiotic square by A.J. Greimas and the notions of negation and opposition that were central to the Paris School of structural semiotics.
Michael Fowler
doaj   +1 more source

Formal Concept Analysis

Electronic Notes in Discrete Mathematics, 1999
Formal concept analysis (FCA) [71] is a mathematical theory for concepts and concept hierarchies that reflects an understanding of “concept” which is first mentioned explicitly in the Logic of Port Royal [2] in 1668 and has been established in the German standard ‘DIN 2330 – Concepts and terms; general principles’ [19].
openaire   +1 more source