Results 61 to 70 of about 381,202 (261)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Formal Concept Analysis of Programming Operation Using Tangible Tool
SICE Journal of Control, Measurement, and System Integration, 2017 This paper describes the structural analysis of the programming operation of the tangible programming tool P-CUBE, which is a tangible block-type programming tool that was developed for use by beginners, including those with visual impairments.
Tatsuo Motoyoshi +4 more
doaj +1 more source
Context-based Project Management
EAI Endorsed Transactions on Context-aware Systems and Applications, 2017 Context-based computing has become an integral part of the software infrastructure of modern society. Better software are made adaptive to suit the surrounding environment.
Ammar Alsaig +2 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Verification of the Formal Concept Analysis
, 2018 This paper is concerned with a formal verification of the Formal Concept Analysis framework. We use the PVS system to represent and formally verify some algorithms of this theory. We also develop a method to transform specifications of algorithms based on finite sets into other executable ones, preserving its correctness.
Alonso Jiménez, José Antonio +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Non-redundant implicational base of formal context with constraints using SAT [PDF]
PeerJ Computer ScienceAn implicational base is knowledge extracted from a formal context. The implicational base of a formal context consists of attribute implications which are sound, complete, and non-redundant regarding to the formal context.
Taufiq Hidayat +2 more
doaj +2 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source