Results 51 to 60 of about 381,202 (261)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Blockchain: Research and ApplicationsNon-fungible token (NFT) is a digital asset whose ownership can be validated and controlled via blockchain technology. The NFT market is a rapidly growing field, and the rarity of NFT is an essential factor that affects its price, as scarcity leads to ...
Heejung Lee +2 more
doaj +1 more source
Extracting Conceptual Relationships and Inducing Concept Lattices from Unstructured Text
Journal of Intelligent Systems, 2019 Concept and relationship extraction from unstructured text data plays a key role in meaning aware computing paradigms, which make computers intelligent by helping them learn, interpret, and synthesis information. These concepts and relationships leverage
Anoop V.S., Asharaf S.
doaj +1 more source
Formal Concept Analysis for Arabic Web Search Results Clustering
Journal of King Saud University: Computer and Information Sciences, 2017 Recently, Arabic language has become one of the most used languages in the web. However, the majority of existing solutions to improve web usage do not take into account the characteristics of this language.
Issam Sahmoudi, Abdelmonaime Lachkar
doaj +1 more source
The formal analysis of concepts [PDF]
Behavior Research Methods, Instruments, & Computers, 1993 The present paper focuses on the extraction, by means of aformal logical/mathematical methodology (i.e., automatically, exclusively by rule), of concept content, as in, for example, continuous discourse. The approach to a fully formal definition of concept content ultimately is owing to a German government initiative to establish “standards” regarding ...
openaire +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source