Results 51 to 60 of about 45,469 (261)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Axioms, 2014 This article presents a simple derivation of optimization models for reaction networks leading to a generalized form of the mass-action law, and compares the formal structure of Minimum Information Divergence, Quadratic Programming and Kirchhoff type ...
Julio Michael Stern, Fabio Nakano
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Hamiltonian formalism in the presence of higher derivatives [PDF]
Theoretical and Mathematical Physics, 2008 A short review of basic formulas from Hamiltonian formalism in classical mechanics in the case when Lagrangian contains N time-derivatives of n coordinate variables. For non-local models N=infinity.
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Epipolar Rectification of a Generic Camera [PDF]
ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information SciencesWe propose a generic method for epipolar resampling that is not tied to a specific camera model. We demonstrate the effectiveness of the approach on a central perspective, pushbroom and pushbroom panoramic camera models. We also devise an epipolarability
M. Pierrot-Deseilligny, E. Rupnik
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Formality of derived intersections
Documenta Mathematica, 2014 We study derived intersections of smooth analytic cycles, and provide in some cases necessary and sufficient conditions for this intersection be formal. In particular, if X is a complex submanifold of a complex manifold
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A formal derivation of the decidability of the theory SA
Theoretical Computer Science, 1994 By \textbf{SA} the authors mean the first order theory of the rationals under addition, with unary functions that give the result of dividing by the positive natural number \(n\) (one for each such \(n\)), and with the \(
Chiharu Hosono, Yasuwo Ikeda
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Topological Derivative-Based Topology Optimization of Linearized Viscous Shallow Water Equation
International Journal of Mathematics and Mathematical SciencesIn this paper, we focus on the derivation of the topological derivative of shallow water equations. We consider two-dimensional viscous shallow-water equations linearized around a constant velocity.
Mame Gor Ngom +3 more
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