Results 61 to 70 of about 34,882,646 (291)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
iiOSProTrain: An Interactive Intelligent Online System for Programming Training
Journal of Advances in Information Technology, 2012 Programming is a crucial skill which is required to be mastered for students on all disciplines of the Computer Science field. For novice students, they always desire explanation and help for all errors encountered in their own solutions. With the recent
Tho Thanh Quan +7 more
doaj +1 more source
A Formal and Quantifiable Log Analysis Framework for Test Driving of Autonomous Vehicles
Sensors, 2020 We propose a log analysis framework for test driving of autonomous vehicles. The log of a vehicle is a fundamental source to detect and analyze events during driving.
Kyungbok Sung +3 more
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
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Teaching Formal Models of Concurrency Specification and Analysis
Моделирование и анализ информационных систем, 2015 There is a widespread and rapidly growing interest to the parallel programming nowadays. This interest is based on availability of supercomputers, computer clusters and powerful graphic processors for computational mathematics and simulation. MPI, OpenMP,
N. V. Shilov
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
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Frontiers in Computational Neuroscience, 2013 Fear conditioning, in which a cue is conditioned to elicit a fear response, and extinction, in which a previously conditioned cue no longer elicits a fear response, depend on neural plasticity occurring within the amygdala.
Thomas eAnastasio
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
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Frontiers in Pharmacology, 2013 According to the amyloid hypothesis, Alzheimer Disease results from the accumulation beyond normative levels of the peptide amyloid-β (Aβ). Perhaps because of its pathological potential, Aβ and the enzymes that produce it are heavily regulated by the ...
Thomas J. Anastasio
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Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
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