Results 31 to 40 of about 2,501,348 (335)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Nominal or Real? The Impact of Regional Price Levels on Satisfaction with Life [PDF]

, 2013
According to economic theory, real income, i.e., nominal income adjusted for purchasing power, should be the relevant source of life satisfaction. Previous work, however, has only studied the impact of inflation adjusted nominal income and not taken into
A E Clark, A E Clark, A Ferrer-I Carbonell, A Ferrer-I-Carbonell, A Finkelstein, A Oswald, A Oswald, A Stutzer, A Stutzer, Armin Falk, B S Frey, B Weber, C Senik, D Kahneman, Di Tella, E Fehr, E Shafir, Efp Luttmer, G Akerlof, G G Wagner, Hannah Schildberg-Hörisch, I Fisher, J Schupp, J Stiglitz, K Fliessbach, M M Grabka, P Dolan, R Chetty, R Kawka, R Layard, S Boes, T Blumkin, Thomas Deckers   +32 more
core   +4 more sources

The need to standardize use of the newly deceased in medical trainings [PDF]

Clinics
OBJECTIVES: The present study aimed to identify the characteristics of use of the deceased in invasive training and the bioethical principles that govern this practice.
Fábio Roberto Cabar, Daniele Costa Rachid Lacerda, Gabriela Thomé Souza de Freitas, Maria Luiza Gorga   +3 more
doaj   +2 more sources

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Informal Authority in the Workplace [PDF]

, 2010
{Excerpt} In most types of organizations, formal authority is located at the top as part of an exchange against fairly explicit expectations. In networked, pluralistic organizations that must rapidly formulate adaptive solutions in an increasingly ...
Serrat, Olivier
core   +1 more source

Agencias socializadoras del control social formal en la prevención del delito contra la vida

Santiago, 2020
En los últimos años se ha experimentado en la provincia de Guantánamo un incremento de la comisión del delito contra la vida evidenciándose una mayor incidencia en las comunidades; escenario importante para el desarrollo histórico de nuestra nación, como
Lilian Lorente-Ocaña, Deneisi Rodríguez-Cardona   +1 more
doaj  

Sociological concept of morale [PDF]

Zbornik Radova: Pravni Fakultet u Novom Sadu, 2012
The author first discusses the overall unity of the total normative regulation, from which it is separated in the late Roman empire the right, but only in the new century and the morale.
Marjanović Miloš
doaj   +1 more source

Models of Strategic Decision-Making under Informational Control

Mathematics, 2021
A general complex model is considered for collective dynamical strategic decision-making with explicitly interconnected factors reflecting both psychic (internal state) and behavioral (external-action, result of activity) components of agents’ activity ...
Dmitry Novikov
doaj   +1 more source