Results 51 to 60 of about 21,706,348 (252)

Tercer Foro Nacional de Control Social: "La importancia del control social para la democracia" [PDF]

open access: yes, 2009
Gestión del conocimientoParticipación ciudadana en Colombia. Rol del sector privado en la promoción del control social - CCB. Enfoque del Modelo de Control Social de la CCB. Líneas de trabajo en Control Social.
Cámara de Comercio de Bogotá
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Formal Specification of a Generic Separation Kernel [PDF]

open access: yes, 2014
Item does not contain fulltextIntransitive noninterference has been a widely studied topic in the last few decades. Several well-established methodologies apply interactive theorem proving to formulate a noninterference theorem over abstract academic ...
Tverdyshev, Sergey   +19 more
core   +1 more source

Paying for Crimes and Earning Heaven. Daily Life of Imprisoned Women at “El Buen Pastor” Penitentiary 1890-1929.

open access: yesHistoria y Memoria, 2015
During the period of Colombian conservative hegemony, “El Buen Pastor” prison, in Bogotá, provides an illustration of penitentiary politics, as well as the formal and informal mechanisms of social control at the time, gathered in a single institution. In
July Andrea García Amézquita
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Proceedings of Formal Methods in Computer Aided Design, FMCAD 2018 [PDF]

open access: yes, 2018
October 30 – November 2, 2018 in Austin, Texas, USATable of Contents: INVITED PAPERS -- Formal Verification of Deep Neural Networks / by Nina Narodytska (p. 1) -- Formal Verification of Unsatisfiability Results / by Marijn Heule (p.
Formal Methods in Computer Aided Design
core  

Master Servant Relationships in the Eastern Cape: the 1820 Settlement

open access: yesAfrican Studies Quarterly, 2021
This article is about the rebellious behavior of the servant class and the consequent threat it posed to the established social order in the 1820 settlement.
Amina Marzouk Chouchene
doaj  

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