Results 31 to 40 of about 457,799 (297)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Agencias socializadoras del control social formal en la prevención del delito contra la vida

open access: yesSantiago, 2020
En los últimos años se ha experimentado en la provincia de Guantánamo un incremento de la comisión del delito contra la vida evidenciándose una mayor incidencia en las comunidades; escenario importante para el desarrollo histórico de nuestra nación, como
Lilian Lorente-Ocaña   +1 more
doaj  

The need to standardize use of the newly deceased in medical trainings [PDF]

open access: yesClinics
OBJECTIVES: The present study aimed to identify the characteristics of use of the deceased in invasive training and the bioethical principles that govern this practice.
Fábio Roberto Cabar   +3 more
doaj   +2 more sources

THE RELATIONSHIP BETWEENACADEMICSUPERIORITY AND PATTERNS OF INFORMAL CONTROL - A FIELD- COMPARATIVES STUDY ON SOME PREPARATORY STAGE STUDENTS FROM TWO VARIANT ENVIRONMENTS IN CAIRO [PDF]

open access: yesJournal of Environmental Science, 2017
It came this study to reveal control methods, both formal and non-formal schools in middle school, and their role in achieving compliance with the students, and to create an atmosphere conducive to excel, so the students are affected by the exercise of ...
Mohamed, T. A.   +2 more
doaj   +1 more source

Trapped by the Lack of Control Over Savings: Evidence From Pakistan

open access: yesFrontiers in Psychology, 2022
Gender discrimination and associated social norms are important contributing factors to the high frequency of women trapped in poverty – particularly in developing countries.
Elisa van Dongen   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

SOCIAL CONTROL OF STATE AUTHORITY BODIES OVER WOMEN OF COMMERCIAL SEX IN MYKOLAYOVSHICHINA IN IN THE NINETEENTH CENTURY

open access: yesПублічне управління та регіональний розвиток
The article analyses the effectiveness of the experience of organizing social control over women of commercial sex in Mykolaiv region in the 19th century.
Svitlana Surgova, Yelyzaveta Titova
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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