Results 81 to 90 of about 2,757,674 (305)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Contingent Control and Wild Moments: Conducting Psychiatric Evaluations in the Home

Social Inclusion, 2019
When social control and social service workers go into the field, into the “native habitat” of some problem, a variety of tacit structures and controls that mark office work with its standardized documents and formal meetings are weakened or absent ...
Robert M. Emerson, Melvin Pollner
doaj   +1 more source

Crowding out Informal Care? Evidence from a Social Experiment in Germany [PDF]

This paper evaluates the effects of a professionally assisted consumer-directed program (Personal Budgets) compared to the standard home care programs of the German long-term care insurance.
Arntz, Melanie, Thomsen, Stephan L.
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Gender and crime: from exclusión to criminalization [PDF]

, 2019
La desigualdad de poder entre hombres y mujeres, producto de una socialización dicotómica y jerárquica, que constituye el imaginario de la sociedad patriarcal, trae como consecuencia que la mujer se vea adscrita a unas conductas estereotipadas, de tal ...
Revelles Carrasco, María
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Better safe than sorry? European farmers’ perceptions on agroecological practices: a theory of planned behaviour case study

Frontiers in Agronomy
Adoption rates of agroecological farming practices remain low amongst European farmers and vary from country to country, despite European or national policies aimed at achieving ‘sustainable agriculture’.
Antonio Paparella, Jacques-Aristide Perrin, James Henty Williams, Bettina Wenzel, Massimiliano Borrello, Hella Kehlenbeck, Julian Winkler, Luigi Cembalo, Samantha M. Cook, Velemir Ninkovic, Aurélie Ferrer, Teresa Del Giudice, Alexander Wezel   +12 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

How Helping Can Reinforce or Attenuate Status Inequalities: The Case of Nonprofit Organizations

RSF: The Russell Sage Foundation Journal of the Social Sciences, 2022
This article examines one type of social exchange that signals status: giving and receiving help. I focus on formal helping exchanges between staff and participants in nonprofit organizations.
Lehn M. Benjamin
doaj   +1 more source

Social gatekeepers and racial equality strategies in social housing [PDF]

This thesis theorises processes of change through an examination of formal and informal race equality strategies within a housing association. The literature review evaluates paradigms which seek to explain the differential housing experiences of ...
Tomlins, Richard
core