Results 181 to 190 of about 1,141,747 (296)

Cellular Snowballing: Cell Adhesion and Migration Drive the Self‐Assembly of Cell‐Microgel Biohybrid Spheroids

Advanced Science, EarlyView.
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie, Sina Kheirabadi, Changhao Li, Aneesh Risbud, Aswathy Sebastian, Istvan Albert, Sulin Zhang, Amir Sheikhi   +7 more
wiley   +1 more source

Advances in synthetic biology for engineering methylotrophic microbial cell factories. [PDF]

J Bacteriol
Guo L, Li R, Gao X, Zhao L, Zhang H.
europepmc   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Antigen anisotropy: The overlooked geometric determinant of vaccine immunogenicity and fidelity. [PDF]

Hum Vaccin Immunother
Santiago D.
europepmc   +1 more source

MOx/Rh Metallene with Energetic Interfaces as Efficient Bifunctional Electrocatalyst for Durable Water Splitting

Advanced Science, EarlyView.
 . ABSTRACT Developing excellent activity and stability bifunctional electrocatalysts for alkaline water splitting remains challenging. This work constructs ultrathin MOx/Rh metallene heterostructures (M = Fe, Co, Ni) via atmosphere‐controlled solvothermal synthesis, achieving uniform MOx nanoclusters on Rh metallene with optimized interfaces. The FeOx/
Ruilong Wei, Yuner Lin, Shanshan Ye, Shuo Wang, Jing Gao, Chaochao Tao, Shengqian Wang, Pei Xiong, Hang Zhang, Hualan Xu, Shengliang Zhong   +10 more
wiley   +1 more source

Flavoring Compound Chemical Class and Vaping Conditions Determine Toxic Carbonyl Emissions from E-Cigarettes. [PDF]

Chem Res Toxicol
Fazeli E, Martinez B, Son Y, Khlystov A.
europepmc   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

Chronic methanol exposure induces cognitive impairment and Alzheimer's-like pathology in rhesus monkeys. [PDF]

Animal Model Exp Med
Li H, Shi C, Li K, Fu X, Lyu Y, Xu Y, Han Y, Liang W, Chuan Q, Zhang L.   +9 more
europepmc   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Machine Learning-Enhanced MEC Sensors with Feature Engineering for Quantitative Analysis of Multi-Component Toxicants. [PDF]

Biosensors (Basel)
Yan J, Liang R, Yan W, Wang X.
europepmc   +1 more source