Results 191 to 200 of about 449,052 (266)

Development of Bioisosteres of Iboga Alkaloids: A Step-Economical Synthesis to Enhance the Antinociceptive and Anxiolytic Activity with Neuroprotective Effects. [PDF]

ACS Pharmacol Transl Sci
Gupta A, Bhattacharya T, Pratihar S, Parvage S, Sharma SN, Sarkar A, De A, Karmakar S, Dey S, Sinha S.   +9 more
europepmc   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Optimizing tissue acquisition to improve the diagnostic yield of endoscopic ultrasound-guided fine needle biopsy of solid masses: a quality improvement initiative. [PDF]

J Can Assoc Gastroenterol
Khan S, Ashrafinia N, Mathura P, Puttagunta L, Girgis S, Thiesen A, Zhang J, Nilsson JE, Wasilenko S, Zepeda-Gomez S, Sandha G.   +10 more
europepmc   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Feasibility of epidermal growth factor receptor and Kirsten rat sarcoma viral oncogene homolog mutation testing in non-plasma body fluids with low tumor cellularity using Idylla®: A proof-of-concept. [PDF]

Cytojournal
Molero A, De la Obra PO, Mate M, Manzanares MP.   +3 more
europepmc   +1 more source

Manufacture of Formalin.

YAKUGAKU ZASSHI, 1903
openaire   +2 more sources

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Short Cationic ACTH-Related Peptides Can Modulate the Na_V1.8 Channel Functioning, Resulting in an Analgesic Effect. [PDF]

Int J Mol Sci
Rogachevskii IV, Kalinina AD, Boichenko NA, Berintseva AV, Plakhova IV, Samosvat DM, Zegrya GG, Butkevich IP, Mikhailenko VA, Penniyaynen VA, Podzorova SA, Kopat VV, Dukhovlinov IV, Krylov BV.   +13 more
europepmc   +1 more source

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source