Results 41 to 50 of about 872,972 (311)
Silyl formates as hydrosilane surrogates for the transfer hydrosilylation of ketones [PDF]
, 2022 R. Martín Romero +5 more
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Regional Radio Stations as Means of Audio Information Transmitting
Вісник Київського національного університету культури і мистецтв. Серія: Аудіовізуальне мистецтво і виробництво, 2020 The purpose of this research is to show the categories of regional broadcasters, their difference from the capital and to explore the problems and benefits of such stations. Research methodology.
Serhii Honcharuk, Nataliia Tsaruk
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Edward Ardizzone’s Multimedial Play with Format in his War Diaries
Interfaces, 2021 The object of my article is Edward Ardizzone’s manuscripts of his four illustrated war diaries (1943-1945) preserved in his archives at the IWM in London, the published edition of his diaries entitled Diary of a War Artist (1974), the larger ink ...
Julie LeBlanc
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Évolutions des temporalités des apprentissages en régime numérique
Distances et Médiations des Savoirs, 2019 Digital technologies have changed the settings of work and leisure activities in space and time. Regarding the schoolwork, digital tools have not modified the relationship to time in learning activities, which still mainly take place in the space of the ...
Anne Lehmans, Camille Capelle
doaj +1 more source
Pigment, light, paper, screen; formats as interacting multi-dimensional creative works
Interfaces, 2021 Formats have an interacting range of qualities that practice based research can explore, so testing and questioning theory; they are more than dimensions.
Tess Baxter
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source