Results 121 to 130 of about 75,479 (241)

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

CO₂ Electroreduction to Formate: Advancing toward Scalable Technologies. [PDF]

ACS Appl Energy Mater
Abarca JA, Díaz-Sainz G, Irabien Á.
europepmc   +1 more source

GLP‐1 agonists and the gut microbiome: A bidirectional relationship

British Journal of Clinical Pharmacology, EarlyView.
Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research.
Srinivas Kamath, Nicole S. L. Chan, Paul Joyce   +2 more
wiley   +1 more source

Carboxydotrophic Acetogenesis in Alkaline Conditions Results in Transient Formate Production by the Halo-Alkaliphilic Acetogen Haloacetibacter carboxydivorans Gen. Nov. sp. Nov. [PDF]

Environ Microbiol Rep
Diender M, Keijsers IM, Galani A, van Roosmalen T, Stams AJM, Sousa DZ.   +5 more
europepmc   +1 more source

A case study showing the role of hydrophobicity variants and other enriched mAb proteoforms on filterability through a virus filter with productivity improvement measures

Biotechnology Progress, EarlyView.
Abstract A rapid assessment of manufacturability for drug candidates is crucial for advancing a prospective biotherapeutic from a candidate to a bulk drug substance. A lot‐to‐lot approach to manufacturability is adopted where each biologic batch is assessed for manufacturability as a bulk, unfractionated pool.
Solomon Isu, Derek Silva, Melissa Holstein, Angela Lewandowski, Kristina Cunningham, Adam Sokolnicki, Bala Raghunath   +6 more
wiley   +1 more source

Determination and Validation of Standard Enthalpies of Formation and Sublimation of Potassium Salts Using Solution Calorimetry and Quantum-Chemical Calculations. [PDF]

ChemistryOpen
Amanollahi Z, Zaitsau DH, Müller K, Bokareva OS, Siewert R.   +4 more
europepmc   +1 more source

Selective Synthesis of N,N‐Dimethylformamide From CO2 Hydrogenation Coupled With Dimethylamine Over a ZnZrOx Solid‐Solution Catalyst

Carbon and Hydrogen, EarlyView.
N‐formylation of dimethylamine though CO2 hydrogenation takes place at a ZnZrOx solid‐solution catalyst surface toward N,N‐dimethylformamide. By synergistic effect of Zn and Zr sites, the catalyst achieves 99% DMF selectivity at 14% DMA conversion at 280°C with at least 1000 h stability on steam.
Jinxin He, Huan Zhang, Junming Yang, Lin Zhang, Fangyun Su, Masheng Yang, Junqi Tian, Xiaoying Chen, Yutong Wang, Jieyun Zhang, Zelong Li   +10 more
wiley   +1 more source

Electrocatalytic CO₂ Reduction Coupled to Formate Fermentation: An Electro-Bio Cascade Approach in Biocompatible Electrolytes. [PDF]

Chemistry
Vieira L, Fabarius JT, Piton GR, Bohlen B, Pangotra D, Speck M, Sagstetter C, Sieber V, Roth A.   +8 more
europepmc   +1 more source

Machine Learning‐Driven Prediction and Optimization of Cu‐Based Catalysts for CO2 Hydrogenation to Methanol

Carbon and Hydrogen, EarlyView.
A machine‐learning framework integrating multimodel prediction, feature selection, and SHAP interpretability is developed to uncover structure–performance relationships of Cu‐based CO2‐to‐methanol catalysts. The optimized XGBoost model and an online prediction platform enable accurate selectivity prediction and data‐driven catalyst design.
Conglong Su, Zhangkai Jing, Qiuming Zhou, Yuan Zhu, Sishi Ye, Tianye Wang, Kuo Chen, Xuebin Luan, Zhigang Tang, Run Xu, Chaopeng Hou, Hongwei Li   +11 more
wiley   +1 more source

Liquid-Phase Syngas-To-Methanol at Low Temperature: Mixed Alcohol Solvent-Controlled Pathways for Circular Carbon Manufacturing. [PDF]

ChemSusChem
Liu G, Hagelin-Weaver H, Pullammanappallil P, Boz Z, Martin-Ryals A, Welt BA.   +5 more
europepmc   +1 more source