Results 61 to 70 of about 4,102,696 (283)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Research on Formation of Microsatellite Communication with Genetic Algorithm

The Scientific World Journal, 2013
For the formation of three microsatellites which fly in the same orbit and perform three-dimensional solid mapping for terra, this paper proposes an optimizing design method of space circular formation order based on improved generic algorithm and ...
Guoqiang Wu, Yuguang Bai, Zhaowei Sun
doaj   +1 more source

Iterative learning-based formation control for multiple quadrotor unmanned aerial vehicles

International Journal of Advanced Robotic Systems, 2020
A double-layer formation control is proposed to solve the repeated tasks for multiple quadrotor unmanned aerial vehicle systems. The first layer aims at achieving a formation target in which the iterative learning control is designed based on relative ...
Zhihui Zhao, Jing Wang, Yangquan Chen, Shuang Ju   +3 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Novel virtual satellite formation scheme for deterministic transmission

Tongxin xuebao, 2023
Although satellite formation flying could effectively support deterministic transmission due to its stable formation, but its formation control required significant real-time computational overhead and did not support flexible deployment for multi ...
Chuan XU, Mi ZHOU, Guofeng ZHAO, Zhaojing CUI, Xiongwen HE   +4 more
doaj   +2 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

PRISMA - Formation Flying Project Close to Launnch [PDF]

, 2010
The PRISMA project is a technical demonstration mission for formation flying and rendezvous in space. The mission can be considered as an in-obit test-bed where different experiments involving Guidance, Navigation and Control (GNC) algorithms, sensors ...
Persson, S., Jörgensen, John, Harr, J., Joergensen, J., Harr, Jon, D'Amico, Simone, D'Amico, S., Persson, Staffan   +7 more
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Fuelless On-Orbit Assembly of a Large Space Truss Structure Using Repulsion of the Service Spacecraft by Robotic Manipulators

Aerospace
A servicing spacecraft motion control approach for the problem of on-orbit truss structure assembly is developed in this paper. It is considered that a cargo container with a rod set and servicing spacecraft are in orbit initially. The assembly procedure
Vladislav Orlov, Uliana Monakhova, Mikhail Ovchinnikov, Danil Ivanov   +3 more
doaj   +1 more source