Results 41 to 50 of about 14,731 (266)

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Histamine formation in flying fish contaminated with Staphylococcus xylosus

International Aquatic Research, 2016
Histamine is the main causative agent of scombroid poisoning. However, unlike scombroid fish, histamine poisoning due to consumption of flying fish has never been reported.
Hsien-Feng Kung, Yi-Chen Lee, Ya-Ling Huang, Chun-Yung Huang, Chiu-Chu Hwang, Yung-Hsiang Tsai   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Nonsingular Fast Terminal Adaptive Neuro-sliding Mode Control for Spacecraft Formation Flying Systems

Complexity, 2020
In this paper, a nonsingular fast terminal adaptive neurosliding mode control for spacecraft formation flying systems is investigated. First, a supertwisting disturbance observer is employed to estimate external disturbances in the system. Second, a fast
Xiaohan Lin, Xiaoping Shi, Shilun Li, Sing Kiong Nguang, Liruo Zhang   +4 more
doaj   +1 more source

Collision Avoidance Algorithm for Satellite Formation Reconfiguration under the Linearized Central Gravitational Fields [PDF]

Journal of Astronomy and Space Sciences, 2013
A collision-free formation reconfiguration trajectory subject to the linearized Hill’s dynamics of relative motion is analytically developed by extending an algorithm for gravity-free space.
InYoung Hwang, Sang-Young Park, Chandeok Park   +2 more
doaj   +1 more source

Sliding Mode Control with Sliding Perturbation Observer-Based Strategy for Reducing Scratch Formation in Hot Rolling Process

Applied Sciences, 2021
In a hot rolling process, excessive friction between rollers and steel plates may lead to the formation of scratches on the steel plate. To reduce scratch formation in the finishing mill of the hot rolling process, two techniques are proposed in this ...
Hyun-Hee Kim, Sung-Jin Kim, Sung-Min Yoon, Yong-Joon Choi, Min-Cheol Lee   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Study on maintaining formations during satellite formation flying based on SDRE and LQR

Open Physics, 2017
Due to the influence of various perturbations of space, satellites flying in formation cannot maintain specific configurations for long durations [1, 2]. In order to ensure that formation configurations are able to meet the requirements of space missions,
Ke Zhang, Zhenqi He, Meibo Lv
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source