Results 111 to 120 of about 18,079,429 (352)

Mechanisms of autophagosome formation

Proceedings of the Japan Academy, Series B
The formation of autophagosomes is a pivotal step in autophagy, a lysosomal degradation system that plays a crucial role in maintaining cellular homeostasis. After autophagy induction, phase separation of the autophagy-related (Atg) 1 complex occurs, facilitating the gathering of Atg proteins and organizes the autophagosome formation site, where the ...
Yuko FUJIOKA, Nobuo N. NODA
openaire   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

A Mechanism for Hadron Molecule Production in p pbar(p) Collisions

, 2013
We propose a mechanism allowing the formation of loosely bound molecules of charmed mesons in high energy proton-(anti)proton collisions.Comment: 4 pages, 3 ...
Esposito, A, Piccinini, F, Pilloni, A, Polosa, AD   +3 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Research on the Manifestation and Formation Mechanism of New Characteristics of Land Disputes: Evidence from the Yangtze River Economic Belt, China

Land
Land disputes have significantly disrupted legal order, production, and social harmony, and has been regarded as a quintessential challenge in public governance, attracting worldwide attentions from scholars.
Shukui Tan, Shangjun Zou, Yi Zhao, Qingsong He, Maomao Zhang   +4 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The Formation Mechanism of Oxide Inclusions in a High-Aluminum Ni-Based Superalloy during the Vacuum Induction Remelting Process

Metals
Oxide inclusions in Ni-based superalloys play a crucial role in determining their mechanical properties, oxidation resistance, and corrosion resistance at high temperatures.
Lihui Zhang, Erkang Liu, Weijie Xing, Zhaojiang Xue, Wenjie Fan, Yunsong Zhao, Yushi Luo, Changchun Ge, Min Xia   +8 more
doaj   +1 more source

Mechanisms of new attachment formation [PDF]

Dental Traumatology, 1987
Abstract A goal of periodontal therapy is predictable regeneration of a periodontium at the site of a previous marginal periodontitis. Current clinical therapeutic techniques result in repair, and not regeneration with formation of a new connective‐tissue attachment. Investigations have shown that surface demineralization of dentin predisposes toward a
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Tails of the Unexpected: The Interaction of an Isothermal Shell with a Cloud

, 2010
A new mechanism for the formation of cometary tails behind dense clouds or globules is discussed. Numerical hydrodynamical models show that when a dense shell of swept-up matter overruns a cloud, material in the shell is focussed behind the cloud to form
Binette, Boss, Cecil, Chu, Cooper, Dyson, Dyson, Falle, Falle, J. M. Pittard, Klein, Leào, López-Martin, Matsuura, Meaburn, Meaburn, Melnick, Nittmann, O'Dell, O'Dell, Ohyama, Pittard, Pittard, Pittard, Rózyczka, Tenorio-Tagle, Tenorio-Tagle, Tenorio-Tagle, Westmoquette, Westmoquette   +29 more
core   +1 more source