Results 111 to 120 of about 4,722,147 (302)

The Formation Mechanism of Oxide Inclusions in a High-Aluminum Ni-Based Superalloy during the Vacuum Induction Remelting Process

Metals
Oxide inclusions in Ni-based superalloys play a crucial role in determining their mechanical properties, oxidation resistance, and corrosion resistance at high temperatures.
Lihui Zhang, Erkang Liu, Weijie Xing, Zhaojiang Xue, Wenjie Fan, Yunsong Zhao, Yushi Luo, Changchun Ge, Min Xia   +8 more
doaj   +1 more source

Graph Transformations and Game Theory: A Generative Mechanism for Network Formation [PDF]

, 2008
Many systems can be described in terms of networks with characteristic structural properties. To better understand the formation and the dynamics of complex networks one can develop generative models.
Cavaliere, Matteo, Csikasz-Nagy, Attila, Jordan, Ferenc   +2 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

In situ Investigations of the Formation Mechanism of Metastable γ‐BiPd Nanoparticles in Polyol Reductions

ChemistryOpen
Synthesizing intermetallic phases containing noble metals often poses a challenge as the melting points of noble metals often exceed the boiling point of bismuth (1560 °C).
Dr. Matthias Smuda, Noah Elsner, Jonas Ströh, Dr. Nicole Pienack, Rastko Radulovic, Dr. Azat Khadiev, Prof. Huayna Terraschke, Prof. Michael Ruck, Prof. Thomas Doert   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Lower Limits of Petrophysical Properties Allowing Natural Gas Accumulation in Marine Sandstones: An Example from the Qiongdongnan Basin, Northern South China Sea

Journal of Marine Science and Engineering
The lower limits of petrophysical properties for an effective reservoir are among the key parameters for assessing hydrocarbon reserves and are therefore directly related to hydrocarbon exploration and development strategies.
Chao Li, Shuai Guo, Qianshan Zhou, Chaochao Xu, Guojun Chen   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source