Results 51 to 60 of about 2,199,507 (268)

Genomic Insights Into Species Divergence and Adaptive Evolution in the Grass Genus Orinus on the Qinghai‐Tibet Plateau

Ecology and Evolution
The grass genus Orinus, endemic to the Qinghai‐Tibet Plateau (QTP), has long been taxonomically controversial. Recent integrative studies combining morphological and DNA barcoding proposed revising the genus from six to three species; however, this ...
Ai Liu, Xue Yang, Juan Lu, Kunjing Qu, Jinyuan Chen, Xu Su, Guangpeng Ren, Hongyin Hu   +7 more
doaj   +1 more source

Formation-Evolutionary Mechanism Analysis and Impacts of Human Activities on the 20 August 2019 Clustered Debris Flows Event in Wenchuan County, Southwestern China

Frontiers in Earth Science, 2021
Characterized by large scale, high frequency, and strong destructiveness, debris flow has become the most noticeable geohazards throughout the world, especially in the mountainous areas of southwestern China.
Yu Li, Xing-nian Liu, Bin-rui Gan, Xie-kang Wang, Xing-guo Yang, Hai-bo Li, Xing-yu Long, Jia-wen Zhou   +7 more
doaj   +1 more source

The mechanics of tumour formation [PDF]

Nature Reviews Cancer, 2019
In a study published in Nature, Messal, Alt et al. report the use of a new imaging technique that has shed light on the morphology of developing tumours within pancreatic ducts.
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

One-step synthesis of high quality kesterite Cu2ZnSnS4 nanocrystals – a hydrothermal approach

Beilstein Journal of Nanotechnology, 2014
The present work demonstrates a systematic approach for the synthesis of pure kesterite-phase Cu2ZnSnS4 (CZTS) nanocrystals with a uniform size distribution by a one-step, thioglycolic acid (TGA)-assisted hydrothermal route.
Vincent Tiing Tiong, John Bell, Hongxia Wang   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source