Results 261 to 270 of about 14,858,533 (317)

Development of Promising Interventions to Improve Human Papillomavirus Vaccination in a School-Based Program in Quebec, Canada: Results From a Formative Evaluation Using a Mixed Methods Design. [PDF]

JMIR Form Res
Dionne M, Sauvageau C, Etienne D, Kiely M, Witteman H, Dubé E.   +5 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Formative evaluation of the implementation of digital therapeutics for opioids and other substance use disorders in primary care (DIGITS trial). [PDF]

Implement Res Pract
Palazzo L, Dorsey CN, Mogk J, Beatty T, King D, Stefanik-Guizlo K, Key D, Matson TE, Shea M, Caldeiro RM, McWethy AG, Wong ES, Idu AE, Glass JE.   +13 more
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Low-Fidelity Prototype of a Sensor-Dependent Interaction Platform: Formative Evaluation With Informal Caregivers of Older Adults With Cognitive Impairment. [PDF]

JMIR Form Res
Sharma N, Grotenhuijs K, Gemert-Pijnen JEWCV, Oinas-Kukkonen H, Braakman-Jansen LMA.   +4 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Pilot implementation of a co-mentoring circles program for the clinical research professionals: Evidence for formative evaluation and logic model. [PDF]

J Clin Transl Sci
Nelson JD, Dunn ME, Levites Strekalova YA.   +2 more
europepmc   +1 more source

A formative evaluation of 'Mind Matters: Overcoming Adversity and Building Resiliency' with Hispanic adolescents prior to and during Covid-19. [PDF]

J Child Adolesc Trauma
Rueda HA, Vera A, Marcial A, Mariano A.
europepmc   +1 more source

Investigating Facilitators and Barriers for Active Breaks among Secondary School Students: Formative Evaluation of Teachers and Students. [PDF]

Children (Basel)
Masini A, Longo G, Ricci M, Scheier LM, Sansavini A, Ceciliani A, Dallolio L.   +6 more
europepmc   +1 more source

Formative Evaluation of a Comprehensive Self-Management Intervention for Irritable Bowel Syndrome, Comorbid Anxiety, and Depression: Mixed Methods Study. [PDF]

JMIR Form Res
Kamp K, Yang PL, Friedman E, Lopez A, Iribarren S, Barney P, Munson S, Heitkemper M, Levy R.   +8 more
europepmc   +1 more source