Results 161 to 170 of about 645 (224)

Doxorubicin‐Induced Cytotoxicity in Adipose‐Derived Stem Cells Is Associated With Altered SAPK/JNK Signaling

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
This study investigated the effects of clinically relevant concentrations of doxorubicin (Dox; 5 μM), commonly used in anticancer therapy, on adipose‐derived stem cells (ADSCs). Dox induced ADSC dysfunction, characterized by reduced mitochondrial activity, apoptosis, oxidative stress, premature senescence, cytoskeletal alterations, and cell cycle ...
Aleksandra Skubis‐Sikora, Kinga Pogoda‐Mieszczak, Bartosz Sikora, Edyta Bogunia, Aleksandra Bryzek, Piotr Czekaj   +5 more
wiley   +1 more source

METTL3/IGF2BP1 influences the development of non-small-cell lung cancer by mediating m6A methylation modification of TRPV1. [PDF]

Thorac Cancer
Bai W, Xiao G, Xie G, Chen Z, Xu X, Zeng J, Xie J.   +6 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, Volume 20, Issue 8, Page 2085-2101, August 2026.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Benzimidazole-Coordinated Copper(II) Complexes as Effectual Chemotherapeutics against Malignancy. [PDF]

ACS Omega
Saha A, Debnath A, Chettri M, Mahato RK, Das D, Sarkar D, Chaurasia R, Bhattacharyya S, Mukherjee M, Biswas B.   +9 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, Volume 20, Issue 8, Page 1986-2007, August 2026.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, Volume 16, Issue 8, Page 1602-1614, August 2026.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Crizotinib- or Ceritinib-Conjugated Platinum(IV) Prodrugs As Potent Multiaction Agents Inducing Antiproliferative Effects in 2D and 3D Cancer Cell Models. [PDF]

J Med Chem
Sharkawy S, Acharya S, Kostrhunová H, Maji M, Marková L, Novohradský V, Gibson D, Brabec V.   +7 more
europepmc   +1 more source

Molecular Docking‐Guided Engineering of TPGS/Tween 80 Mixed Micelles for the Intranasal Delivery of Paliperidone Palmitate

Advanced Therapeutics, Volume 9, Issue 8, August 2026.
A nanoscale drug delivery system is developed to improve how an antipsychotic reaches the brain. Using computer‐guided design, mixed micelles are engineered to enhance drug solubility and nasal transport. The system shows improved release and effectiveness in animal models, reducing symptoms while maintaining brain safety and structure.
Poorva Maske, Rati Kailash Prasad Tripathi, Singdha Das Mandal, Pranav Shah, Nimeet Desai, Manisha Lalan   +5 more
wiley   +1 more source

Bacillus velezensis GH1-13 enhances drought tolerance in rice by reducing the accumulation of reactive oxygen species. [PDF]

Front Plant Sci
Park D, Jang J, Seo DH, Kim Y, Jang G.
europepmc   +1 more source

Modulation of Prostate Cancer Cell Behavior Through Acetylsalicylic Acid‐Treated Prostate Epithelial Cell‐Derived Conditioned Medium

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Acetylsalicylic acid (ASA, aspirin), derived from salicylic acid in willow bark, is known for its analgesic, anti‐inflammatory, and antiplatelet properties. Beyond cardiovascular protection, increasing evidence suggests that ASA may reduce the risk of various cancers, including colorectal and prostate cancer.
Dilşad Özerkan, Selda Durukan, Mahsa Koucheki, Aysel Nesil   +3 more
wiley   +1 more source