Results 71 to 80 of about 1,821 (267)

Mitochondrial Enzymes Mimetic Ultrasmall Palladium Nanozymes Prevent Senescence and Neurodegeneration Through Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Simply constructed polyvinylpyrrolidone (PVP) modified palladium nanoparticles (PdP NPs) as cytochrome c oxidase (CcO) and superoxide dismutase (SOD) mimic are promising multifunctional nanoreactors to boost mitochondrial respiration chain function and refine homeostasis via regulation of mitochondrial dynamics and proteostasis sensor UPRmt, which ...
Wenshu Cong   +8 more
wiley   +1 more source

Використання реакції Ульмана в синтезі формазанів [PDF]

open access: yes, 2011
Дана робота присвячена синтезу формазанів, які знайшли застосування в якості термо- та фото-хромних матеріалів. Окрім того, якщо в структуру формазану ввести деякі фрагменти, то вони будуть володіти люмінесцентними властивостями.
Дістанов, В. В.   +3 more
core  

The intramitochondrial localization of succinate-yellow tetrazolium reductase with the electron microscope [PDF]

open access: yes, 1971
A new tetrazolium salt, yellow tetrazolium, has been used to localise succinatetetrazolium reductase with the electron microscope. As expected, the formazan did not give high contrast in the optical microscope, but localization with the EM was good.
Bradbury, S.   +2 more
core   +1 more source

Synthesis and biological evaluation of formazan derivatives

open access: yesJournal of Advanced Pharmaceutical Technology & Research, 2010
The formazan derivatives (FM1-FM5) were synthesized by the reaction of benzaldehyde phenylhydrazone with substituted aromatic and hetero aromatic amines. The structures of the synthesized compounds were then elucidated using UV, IR, (1)H NMR and mass spectral data.
Gurusamy Mariappan   +6 more
openaire   +4 more sources

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

open access: yesAdvanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li   +6 more
wiley   +1 more source

Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets [PDF]

open access: yes, 2018
Aims/hypothesis: Glutamate dehydrogenase (GDH) is a mitochondrial enzyme playing a key role in the control of insulin secretion. However, it is not known whether GDH expression levels in beta cells are rate-limiting for the secretory response to glucose.
Bartley, C.   +5 more
core  

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

open access: yesAdvanced NanoBiomed Research, EarlyView.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura   +14 more
wiley   +1 more source

Oxytocin‐ und Vasopressin‐Photosonden zur Entschlüsselung der Neuropeptid‐Signalgebung mit hoher räumlicher und zeitlicher Präzision

open access: yesAngewandte Chemie, EarlyView.
Neue biokompatible Oxytocin‐ und Vasopressin‐Photosonden mit modernsten Photocages. Diese Photosonden sind inaktiv und können mit spezifischen Lichtwellen entschützt werden, was eine Rezeptoraktivierung mit hoher zeitlicher und räumlicher Kontrolle ermöglicht. Abbildung erstellt mit https://BioRender.com ZUSAMMENFASSUNG Das Oxytocin/Vasopressin (OT/VP)
Konstantin Raabe   +7 more
wiley   +1 more source

Cationic Boron Formazanate Complexes [PDF]

open access: yes, 2021
This thesis describes the synthesis and characterization of various three- and four-coordinate cationic and dicationic boron complexes supported by formazanate ([R1-N-N=C(Ph)-N=N-R5]− ligands. The first chapter provides a review of various three-coordinate and cationic boron complexes and related applications. Chapter two examines the effect of several
openaire  

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