Results 121 to 130 of about 1,068,274 (302)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
MATEC Web of Conferences, 2018 The paper presents investigations on a forming process, which is implemented in a forming press based on a Stewart platform. In contrast to common forming techniques, this buildup offers not only one but six degrees of freedom.
Wonnenberg Birk +2 more
doaj +1 more source
Weld peaking on heavy aluminum structures [PDF]
Weld peaking is usually undesirable in any welded structure. In heavy structures, the forces involved in the welding process become very large and difficult to handle.
Bayless, E., Poorman, R., Sexton, J.
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Study of Electromagnetic Forming of Cylindrical Workpieces Based on Equivalent Electrical Circuit [PDF]
Journal of Electrical and Electronics Engineering, 2008 Electromagnetic forming is a method ofmetal working by plastic deformation, under theaction of forces acting on the conductor in a rapidlyvarying magnetic field obtained by discharging abattery of condensers through a forming coil.
Paşca Sorin, Tomşe Marin
doaj
New Bound States of Top-anti-Top Quarks and T-balls Production at Colliders (Tevatron, LHC, etc.)
, 2008 The present talk is based on the assumption that New Bound States (NBSs) of top-anti-top quarks (named T-balls) exist in the Standard Model (SM): a) there exists the scalar 1S - bound state of 6t+6\bar t - the bound state of 6 top-quarks with their 6 ...
Das, C. R. +4 more
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source