Results 141 to 150 of about 366,377 (310)

Limit-Forms of Time

Critical Hermeneutics
To establish what time is, as in Plato’s iconic definition (“moving image of eternity”, Timaeus 37d), one often has to emphasize its relation to what time is not. Time seems to be defined dialectically, in terms of what is not eternal, not extra-temporal, etc.
openaire   +3 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Forming Limit Diagram of Stainless Steel-Aluminum Alloy Clad

, 2010
The forming limit diagram of clad was developed with Hill’s instability criterion and M–K analysis at the positive strain ratio. The relationships of forming limit with stain path, thickness ratio and thickness irregular coefficient were analyzed.
Hong Wei Liu, Peng Zhang
core   +1 more source

Study on Incremental Sheet Forming Performance of AA2024 Aluminum Alloy Based on Adaptive Fuzzy PID Temperature Control

Metals
The development of technology has driven a rising need for high-accuracy and high-efficiency manufacturing of low-volume products. Incremental forming technology, characterized by die-free flexibility and low production costs, can effectively replace ...
Zhengfang Li, Zhengyuan Gao, Kaiguo Qian, Lijia Liu, Jiangpeng Song, Shuang Wu, Li Liu, Xinhao Zhai   +7 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Parametric failure limit detection for the sheet metal forming of a floating photovoltaic (FPV) aluminum alloy structure [PDF]

The sheet metal forming process of a floating photovoltaic (FPV) structure is simulated in LS-DYNA. An anisotropic yield criterion and a two-term Voce hardening law are used to model the plastic behavior of AA5083-H111 sheets.
Reyes, Aase, Erduran, Emrah, Tveit, Sigbjørn   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The effect of strain path over the forming limit diagram and forming limit stress diagram used in the simulation of sheet metal forming process

, 2002
Lucrarea se ocupă de determinarea curbelor limită pentru deformaţii şi a curbelor limită pentru tensiuni la apariţia stricţiunii prin utilizarea unor încercări cum sunt încercarea la tracţiune, compresiune şi încercarea prin metoda Marciniak.
UNGUREANU, V.
core