Results 71 to 80 of about 1,031,084 (269)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Research on microstructure evolution and carbide transformation behavior during the quenching and tempering processes of secondary hardening steel

Journal of Materials Research and Technology
The microstructure evolution, solution and precipitation of precipitated phases and mechanical properties of Co-free and low-Ni secondary hardening steel, upon quenching and tempering were studied using optical microscopy (OM), transmission electron ...
Yaxu Zheng, Shaokang Chu, Long Zhang, Qi Wang, Guibao Qiu, Liguang Zhu, Zhihong Guo, Tianwei Xie, Hairui Zhao, Suling Lu, Bo Wang, Jie Feng   +11 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Interface enhancement mechanism of rolled Mg/Al clad plate with particle interface control

Journal of Magnesium and Alloys
In this study, the cold-spraying process was utilized to deposit Al particles onto an Al slab, an Mg slab, and both Al and Mg slabs to form an ultra-thin interlayer, and then the clad slabs were rolled at 400 °C, developing three roll-bonding processes ...
Xiaobao Ma, Peng Li, Tao Wang, Zhongkai Ren, Peng Chen, Jiang Ji   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Preliminary data on the ornithological fauna of the islet forming in the south part of Musura Gulf , between Stambulul Vechi (Ukraine) and Sulina (Romania) branches of the Danube [PDF]

Scientific Annals of the Danube Delta Institute, 2008
For several tens of years, Sacalin Island has been regarded as the classic example of a new biotope forming in the easternmost part of the Danube, resulted as an interaction between the river and the Black Sea, host to specific flora and fauna; presently,
KISS János Botond, MARINOV Mihai, ALEXE Vasile   +2 more
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Theoretical and Experimental Research on the Forming Process of Tube by the Tandem Skew Rolling Process

Engineering Reports
To investigate the forming mechanisms and force conditions of a tube blank during tandem skew rolling (TSR), force analysis diagrams were created for each stage of the process.
Feilong Mao, Jianguo Liang, Yuanhua Shuang, Fujie Wang, Jianhua Hu, Bo Wang   +5 more
doaj   +1 more source