Results 51 to 60 of about 209,697 (224)
Cybrarians Journal, 2010 Libraries and the information services they provide on the Internet face a set of challenges imposed by rapid developments in information technology and remote communications. The direct search service in the library catalog is one of the most prominent
Mohamed Helmy
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Cybrarians Journal, 2009 Libraries and the information services they provide on the Internet face a set of challenges imposed by rapid developments in information technology and remote communications.
Mohamed Helmy
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
康复学报, 2022 Since 2016, Peking University Third hospital has been entrusted by the National Health Commission to undertake the work of National Center for Healthcare Quality Management in Rehabilitation Medicine.
ZHOU Mouwang
doaj
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
TREATMENT OF EPILEPSY IN PATIENTS OF “VU LNERABLE” AGE: THE ADOLESCENTS AND THE ELDERLY
Эпилепсия и пароксизмальные состояния, 2017 The incidence of epilepsy is highest in children and in elderly people (over 60 years of age). In about 75% of cases, the first seizures occur before the age of 16 with the maximal occurrence observed before the age of 10 [1].
K. V. Voronkova +3 more
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Designing a Form for Request to Transfusion of Blood and Its Products
مدیریت اطلاعات سلامت, 2010 One of the methods for knowledge transferring is documentation of procedures done in a documentary process, whether in a paper or electronic format. For creation reporting process of monitoring the rate of blood request, uses, and reactions, also unused ...
Azar Kabirzadeh +4 more
doaj