Results 51 to 60 of about 664,961 (249)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Modelling the role of credit rating agencies : Do they spark off a virtuous circle? [PDF]

, 2005
In this paper, we propose a model of credit rating agencies using the global games framework to incorporate information and coordination problems.
Bannier, Christina E., Tyrell, Marcel
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Building the Eurocracy: The Politics of EU Agencies and Networks [PDF]

, 2007
This paper explores both the politics behind and the policy impacts of the design of EU regulatory institutions. The EU has established an extensive ‘Eurocracy’ outside of the Commission hierarchy, including over two dozen European agencies and a number ...
Tarrant, Andy,, Kelemen, R. Daniel.
core  

Research Support In Policy Formulation At The Border Management Agency Of North Central Timor District

Jurnal Ilmiah Ilmu Administrasi Publik, 2020
This study aimed (1) to analyze the role of research results in the formulation of border management policies in North Central Timor Regency conducted by the Regional Border Management Agency of North Central Timor Regency and (2) to analyze the obstacles faced by the Regional Border Management Agency in applying research results in the process of the ...
Yohanes Fritantus, Makarius Erwin Bria
openaire   +3 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

LABOR RESOURCES AND LABOR UTILIZATION IN VINH CITY, NGHE AN PROVINCE IN THE PERIOD 2012-2022

Tạp chí Khoa học
Labour resources and employment are top concerns in the socio-economic development strategies of every country and locality on the path of development. This article analyses and clarifies the current state of labour resources and employment in Vinh City
Phan Thi Van
doaj   +1 more source

Examining the Management of Job Engagement and Job Decisions' Impact on Local Government Officials' Perception of Prestige

Zeszyty Naukowe Wyższej Szkoły Finansów i Prawa w Bielsku-Białej, 2023
This article delves into the multifaceted landscape of local government employees' job decisions (JD) and job engagement (JE) by investigating their tenure intentions.
Włodzimierz Strelcow, Iuliia Padafet, Nadiia Shmygol   +2 more
doaj   +1 more source