Results 51 to 60 of about 2,295,718 (333)

Problematising the Global in Global IR

open access: yes, 2020
International Relations (IR) has long been criticised for taking a particular (Western) experience as basis for formulating theories with claim to universal validity.
Felix Anderl, Antonia Witt
semanticscholar   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Healthcare Waste Management in Nigeria: A Review

open access: yesRecycling, 2022
Healthcare waste management has become an important aspect of medical care delivery globally. This is simply because of its hazardous and infectious components that have greater potential for adverse health and environmental impacts.
Obiora B. Ezeudu   +6 more
doaj   +1 more source

Industrial Sources of Dioxin Poisoning in Mossville, Louisiana: A Report Based on the Government's Own Data [PDF]

open access: yes, 2007
Since 1998, the U.S. Agency for Toxic Substances and Disease Registry (ATSDR) -- which is a division of the Centers for Disease Control -- has conducted an Exposure Investigation of dioxins in Mossville, Louisiana, an historic African American community ...
Wilma Subra
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

LABOR RESOURCES AND LABOR UTILIZATION IN VINH CITY, NGHE AN PROVINCE IN THE PERIOD 2012-2022

open access: yesTạp chí Khoa học
Labour resources and employment are top concerns in the socio-economic development strategies of every country and locality on the path of development. This article analyses and clarifies the current state of labour resources and employment in Vinh City
Phan Thi Van
doaj   +1 more source

Introduction: The Debate Over Independent Agencies in Light of Empirical Evidence [PDF]

open access: yes, 1988
Constitutional theory has rediscovered the problem of governmental structure. As the rights revolution has matured and entered the mainstream, the debate is returning to the question that preoccupied the Founding Fathers: what organization of government ...
Miller, Geoffrey P.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Examining the Management of Job Engagement and Job Decisions' Impact on Local Government Officials' Perception of Prestige

open access: yesZeszyty Naukowe Wyższej Szkoły Finansów i Prawa w Bielsku-Białej, 2023
This article delves into the multifaceted landscape of local government employees' job decisions (JD) and job engagement (JE) by investigating their tenure intentions.
Włodzimierz Strelcow   +2 more
doaj   +1 more source

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