Results 41 to 50 of about 10,818 (263)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Healthcare Waste Management in Nigeria: A Review

Recycling, 2022
Healthcare waste management has become an important aspect of medical care delivery globally. This is simply because of its hazardous and infectious components that have greater potential for adverse health and environmental impacts.
Obiora B. Ezeudu, Tochukwu S. Ezeudu, Uzochukwu C. Ugochukwu, Imokhai Theophilus Tenebe, Agbaji P. Ajogu, Uchenna V. Nwadi, Charles C. Ajaero   +6 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

LABOR RESOURCES AND LABOR UTILIZATION IN VINH CITY, NGHE AN PROVINCE IN THE PERIOD 2012-2022

Tạp chí Khoa học
Labour resources and employment are top concerns in the socio-economic development strategies of every country and locality on the path of development. This article analyses and clarifies the current state of labour resources and employment in Vinh City
Phan Thi Van
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Research progress on evaluation index system of nursing quality in nursing homes

Huli yanjiu, 2018
This paper introduced the research on the evaluation index system of nursing quality in nursing home institutions at home and abroad,analyzed the problems in the quality of nursing services in pension agencies in China,and aiming to draw lessons from ...
王春霞, 纪代红, 李亮
doaj  

Examining the Management of Job Engagement and Job Decisions' Impact on Local Government Officials' Perception of Prestige

Zeszyty Naukowe Wyższej Szkoły Finansów i Prawa w Bielsku-Białej, 2023
This article delves into the multifaceted landscape of local government employees' job decisions (JD) and job engagement (JE) by investigating their tenure intentions.
Włodzimierz Strelcow, Iuliia Padafet, Nadiia Shmygol   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

UPDATING AND HARMONIZING LEGISLATION: A PROACTIVE STEP IN COMBATING TRANSNATIONAL ORGANIZED CRIME

სამართალი და მსოფლიო
Organized crime has emerged as one of the most formidable challenges globally, existing as an unavoidable reality with such severe implications that the international community is compelled to unite efforts to counteract it.
Horiya Souiki, Mohamed Bessas
doaj   +1 more source