Results 41 to 50 of about 675,791 (300)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Modelling the role of credit rating agencies : Do they spark off a virtuous circle? [PDF]
, 2005 In this paper, we propose a model of credit rating agencies using the global games framework to incorporate information and coordination problems.
Bannier, Christina E., Tyrell, Marcel
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Building the Eurocracy: The Politics of EU Agencies and Networks [PDF]
, 2007 This paper explores both the politics behind and the policy impacts of the design of EU regulatory institutions. The EU has established an extensive ‘Eurocracy’ outside of the Commission hierarchy, including over two dozen European agencies and a number ...
Tarrant, Andy,, Kelemen, R. Daniel.
core
Jurnal Ilmiah Ilmu Administrasi Publik, 2020 This study aimed (1) to analyze the role of research results in the formulation of border management policies in North Central Timor Regency conducted by the Regional Border Management Agency of North Central Timor Regency and (2) to analyze the obstacles faced by the Regional Border Management Agency in applying research results in the process of the ...
Yohanes Fritantus, Makarius Erwin Bria
openaire +3 more sources
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Shuitu baochi yanjiu, 2008 A set of finance management regulations suitable for interior agencies’ use should be formulated to ensure the financial secure operation among project interior agencies upon implementing donor’ s projects.In this article,in line with the properties of ...
DU Qing, HE Lin, XIE Yan-fang
doaj
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source