Results 31 to 40 of about 244,082 (296)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Gutachten zu Forschung, Innovation und technologischer Leistungsfähigkeit Deutschlands 2013 [PDF]
, 2013 Die Expertenkommission Forschung und Innovation legt mit dem Jahresgutachten 2013 aktuelle Analysen, Bewertungen und Empfehlungen zur Gestaltung des deutschen Forschungs- und Innovationssystems vor.
EFI - Expertenkommission Forschung und Innovation
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Auswirkungen des EU-Pharmapakets auf Europas Innovationsfähigkeit
Monitor VersorgungsforschungDie EU arbeitet gerade ein neues Pharmapaket aus, welches sich zum Ziel setzt die Sicherheit, Wirksamkeit und Qualität von Arzneimitteln zu gewährleisten.
Alexander Tamdjidi, Juliane Haug
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Organisationale Rahmenbedingungen für Integrierte Forschung
, 2022 S.119-132Verantwortliche Forschung und Innovation (Responsible Research and Innovation,RRI) zielt darauf ab, Forschung und Innovation stärker mit gesellschaftlichen Bedarfen und Werten in Austausch zu bringen.
Röß, Andreas, Warnke, Philine
core +1 more source
How phagocytic cells kill bacteria: Lessons from a professional killer
FEBS Open Bio, EarlyView.How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley +1 more source
, 2005 Investitionen in Bildung und Forschung sind Grundlage für Wachstum, Beschäftigung und gesellschaftlichen Fortschritt. Besonders in zentralen Innovationsfeldern des 21.
Bundesministerium für Bildung und Forschung
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FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source