Results 41 to 50 of about 38,654 (260)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The K-Nearest Neighbor algorithm using Forward Selection and Backward Elimination in predicting the Student’s Satisfaction Level of University Ichsan Gorontalo toward Online Lectures during the COVID-19 Pandemic

Ilkom Jurnal Ilmiah, 2023
Academic services are actions taken by state and private universities to provide convenience for student’s academic activities. During the current covid-19 pandemic, every university remains active in academic activities.
Andi Bode, Zulfrianto Y Lamasigi, Ivo Colanus Rally Drajana   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A genetic algorithm for scheduling multimode resource-constrained project problem in the presence of preemptive resources [PDF]

Journal of Project Management, 2019
In this paper, a backward approach is proposed for maximizing net present value (NPV) in multi-mode resource constrained project scheduling problem while assuming discounted positive cash flows (MRCPSP-DCF). The progress payment method is used and all re-
Aidin Delgoshaei, Sepehr Esmaeili Hanjani , Amir Hossein Nasiri   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A Forward–Backward–Forward Algorithm for Quasi-Variational Inequalities in the Moving Set Case

Mathematics
This paper addresses the challenge of solving quasi-variational inequalities (QVIs) by developing and analyzing a forward–backward–forward algorithm from a continuous and iterative perspective.
Nevena Mijajlović, Ajlan Zajmović, Milojica Jaćimović   +2 more
doaj   +1 more source

Research on Dynamic Incremental Backward Cloud Transformation Algorithm [PDF]

Jisuanji kexue
As a tool for studying uncertain information,cloud model is of great significance in uncertain artificial intelligence and data mining.The backward cloud transformation algorithm is one of the important algorithms of cloud model,which can realize the ...
XU Changlin, KONG Lingzhuo
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

On the Concatenated Transmission Scheme With the Low-Complexity Symbol-Level Watermark Decoder for Recovering the Synchronization

IEEE Access, 2019
The Davey–MacKay (DM) concatenated code employing the symbol-level watermark decoding algorithm is able to correct a large number of binary insertions, deletions, and substitutions, while it has the high computational complexity for recovering the
Yuan Liu
doaj   +1 more source

Shape Optimization of Labyrinth Seals to Improve Sealing Performance

Aerospace, 2021
To reduce gas leakage, shape optimization of a straight labyrinth seal was carried out. The six design parameters included seal clearance, fin width, fin height, fin pitch, fin backward, and forward expansion angle. The CFD (Computational Fluid Dynamics)
Yizhen Zhao, Chunhua Wang
doaj   +1 more source