Results 41 to 50 of about 1,679,670 (240)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Treatment Adherence and Adherence Patterns of Tofacitinib and Self‐Injectable TNFi Use in People with Rheumatoid Arthritis

ACR Open Rheumatology
Objective To assess tofacitinib and self‐injectable tumor necrosis factor inhibitor (TNFi) adherence using the Medication Event Monitoring System (MEMS) and characterize association with adherence in patients with rheumatoid arthritis (RA).
Kaleb Michaud, Sofia Pedro, Eric Tousset, Rebecca Schumacher, Ekta Agarwal, Bernard Vrijens   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Hedging Training for Export and Import Business

Journal of Innovation and Community Engagement, 2023
Globalization causes changes and provides convenience in trading activities between countries, exports, and imports. This community service program was conducted for a company engaged in the field of iron trading, which deals with imported products from ...
Margarita Ekadjaja, Amory Takahiro Theja, Wilson Wijaya   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

TOOL FORECASTING METHODS OF LEVEL OF THE PRICE ON THE FORWARD MARKET OF FORTS

Вестник Северо-Кавказского федерального университета, 2022
Investments into the market of derivative financial instruments gain the increasing popularity. In article the concept of the forward market, and also price forecasting methods, such as the fundamental and technical analysis is considered.
Denis Lovyannikov, Irina Glazkova
doaj  

عقود الصرف الآجلة وعقود مبادلة العملات (Forward - Swap) وبدائلها الشرعية

Cumhuriyet İlahiyat Dergisi, 2021
يتناول البحث عقود الصرف الآجلة (Forward) وعقود مبادلة العملات أو ما يسمى بمقايضة العملات (Swap)، ويعتبر هذان النوعان من العقود من أبرز أنواع عقود المشتقات المالية التي نشأت بعد انهيار نظام بريتون وودز عام 1971 أو ما يسمى بصدمة نيكسون، حيث تم فك الارتباط
Zeynelabidin Hayat
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Self-Contrastive Forward-Forward algorithm

Nature Communications
Agents that operate autonomously benefit from lifelong learning capabilities. However, compatible training algorithms must comply with the decentralized nature of these systems, which imposes constraints on both the parameter counts and the computational resources. The Forward-Forward (FF) algorithm is one of these.
Xing Chen, Dongshu Liu, Jérémie Laydevant, Julie Grollier   +3 more
openaire   +2 more sources