Results 61 to 70 of about 977,095 (294)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

DIAGNOSIS OF CUCUMBER PLANT DISEASES USING CERTAINTY FACTOR AND FORWARD CHAINING METHODS

Techno Nusa Mandiri: Journal of Computing and Information Technology
Cucumber plants spread and can live in tropical climates like Indonesia. The cucumber plant has many benefits and can be a beauty ingredient. Cucumbers, like other plants, can also have disease attacks, which can threaten farmers.
Bligania Bligania, Yoga Pristyanto, Heri Sismoro, Yuli Astuti, Anggit Ferdita Nugraha   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Designing a safe forward chaining tactic using productive proofs

International audienceWe present a proof-theoretic treatment of forward chaining and saturation within a multisorted, first-order intuitionistic logic with equality.
Gantait, Arunava, Chaudhuri, Kaustuv, Miller, Dale   +2 more
core   +5 more sources

Sistem Pakar Antisipasi Kegagalan Pengembangan Sistem Informasi dengan Pendekatan Forward Chaining

Elkawnie: Journal of Islamic Science and Technology, 2017
Dalam pengembangan sistem informasi, kemungkinan kesalahan atau kegagalan (failure) cukup tinggi dan acap kali terjadi kasus kegagalan yang berulang yang dapat berakibat fatal bagi kelangsungan transaksi sistem pada suatu organisasi, sehingga penting ...
Khairan AR
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Multivariate analysis of trip-chaining behavior [PDF]

Trip-chaining behavior has generally been associated with various demographic characteristics of households and individuals. This includes households with children having more complex activity patterns, or those who are employed needing to conduct ...
Robert Noland, John V. Thomas
core  

Pembuatan inference engine sistem pakar dengan metode forward chaining dan atau backward chaining

, 2008
VP-Expert merupakan sebuah program sistem pakar yang berbasis DOS dan menggunakan backward chaining sebagai teknik pemecahan masalah. Akan tetapi fitur yang dimiliki VP-Expert terbatas misalnya hanya terbatas pada satu metode yaitu bacward chaining dan ...
Setyabudi, Andre
core   +1 more source