Results 71 to 80 of about 977,095 (294)

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

PERBANDINGAN METODE FORWARD CHAINING DAN BACKWARD CHAINING PADA SISTEM PAKAR DIAGNOSIS PENYAKIT IKAN LELE SANGKURIANG [PDF]

open access: yes, 2019
Kesulitan melakukan diagnosis penyakit ikan lele sangkuriang menjadi kendala bagi siswadan siswi Sekolah Menengah Kejuruan 1 Kademangan di Kabupaten Blitar.
Abdi Pandu Kusuma   +3 more
core   +1 more source

Expert System for Diagnosis of Plant Pest and Disease Horticulture with Forward and Backward Chaining Inference

open access: yesJurnal Teknologi dan Sistem Komputer, 2017
One of the obstacles to doing cultivation of horticulture plant is to overcome pest and disease. Pest and disease attack can decrease productivity and even causes harvest fail that influence toward one of income sources in the country.
Ginanjar Wiro Sasmito
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Expert System for Diagnosing Diseases in Rubber Plants using the Forward Chaining and Dampster Shafer Methods

open access: yesSistemasi: Jurnal Sistem Informasi
Rubber plants are important crops in various countries. Rubber plants have many benefits for human life. Rubber plant diseases cause many losses to farmers.
Indri Ayu Ningrum   +2 more
doaj   +1 more source

Study on Forward Chaining and Reverse Chaining in Expert System

open access: yesInternational Journal of Advanced Engineering Research and Science, 2016
Expert systems are part of a general category of computer applications known as intelligence. Expert system are designed to solve complex problems. Expert Systems is a branch of AI designed to work within a particular domain. To solve expert-level problems, expert systems will need efficient access to a substantial domain knowledge base, and a ...
Ashwini Rupnawar   +2 more
openaire   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Making forward chaining relevant

open access: yes, 1998
Planning by forward chaining through the world space has long been dismissed as being “obviously ” infeasible. Nevertheless, this approach to planning has many advantages.
Fahiem Bacchus
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

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