Results 91 to 100 of about 29,606,688 (333)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Novel Airborne EM Image Appraisal Tool for Imperfect Forward Modelling [PDF]

open access: green, 2022
Wouter Deleersnyder   +2 more
openalex   +1 more source

SLiM 3: Forward Genetic Simulations Beyond the Wright–Fisher Model

open access: yesbioRxiv, 2018
With the desire to model population genetic processes under increasingly realistic scenarios, forward genetic simulations have become a critical part of the toolbox of modern evolutionary biology.
B. Haller, Philipp W. Messer
semanticscholar   +1 more source

Re-epithelialization and immune cell behaviour in an ex vivo human skin model

open access: yesScientific Reports, 2020
A large body of literature is available on wound healing in humans. Nonetheless, a standardized ex vivo wound model without disruption of the dermal compartment has not been put forward with compelling justification.
A. Rakita   +4 more
semanticscholar   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Editorial for the Special Issue “Sea Surface Salinity Remote Sensing”

open access: yesRemote Sensing, 2019
This Special Issue gathers papers reporting research on various aspects of remote sensing of sea surface salinity (SSS) and the use of satellites SSS in oceanography. It includes contributions presenting improvements in empirical or theoretical radiative
Emmanuel Dinnat, Xiaobin Yin
doaj   +1 more source

Gradient Forward-Propagation for Large-Scale Temporal Video Modelling [PDF]

open access: green, 2021
Mateusz Malinowski   +4 more
openalex   +1 more source

A Nonlinear Force-Free Magnetic Field Approximation Suitable for Fast Forward-Fitting to Coronal Loops. II. Numeric Code and Tests

open access: yes, 2012
Based on a second-order approximation of nonlinear force-free magnetic field solutions in terms of uniformly twisted field lines derived in Paper I, we develop here a numeric code that is capable to forward-fit such analytical solutions to arbitrary ...
A. Gary   +32 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

A Forward, Analytic, Differentiable, Geometric (but Inflexible) Lens Model

open access: yesGalaxies
We anticipate that hundreds of thousands of distant, strongly gravitationally lensed sources will be detectable with European Space Agency’s (ESA) Euclid mission and the Rubin Observatory Legacy Survey of Space and Time.
Paul L. Schechter
doaj   +1 more source

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