Results 71 to 80 of about 29,606,688 (333)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Forward Operator Estimation in Generative Models with Kernel Transfer Operators [PDF]
, 2021 Zhichun Huang +2 more
openalex +1 more source
Delayed Feedback Control Requires an Internal Forward Model [PDF]
, 2009 Biological motor control provides highly effective solutions to difficult control problems in spite of the complexity of the plant and the significant delays in sensory feedback .
Meir, Ron, Volkinshtein, Dmitry
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Forward modeling of δ18O in Andean ice cores
Geophysical Research Letters, 2016 Tropical ice core archives are among the best dated and highest resolution from the tropics, but a thorough understanding of processes that shape their isotope signature as well as the simulation of observed variability remain incomplete. To address this,
J. V. Hurley, M. Vuille, D. R. Hardy
doaj +1 more source
Frontiers in Human Neuroscience, 2019 Central to the mechanistic understanding of the human mind is to clarify how cognitive functions arise from simpler sensory and motor functions. A longstanding assumption is that forward models used by sensorimotor control to anticipate actions also ...
Lin Lawrence Guo +3 more
doaj +1 more source
The N - Jet Inclusive Cross-Section in the Hard Pomeron Model [PDF]
, 1997 The inclusive production of several jets is studied in the framework of the hard pomeron model. The average jet momenta are found to be strongly ordered and growing towards the central c.m. rapidity, as expected.
Braun, Mikhail, Treleani, Daniele
core +2 more sources
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Cultural Differences in Perceiving Sounds Generated by Others: Self Matters
Frontiers in Psychology, 2015 Sensory consequences resulting from own movements receive different neural processing compared to externally generated sensory consequences (e.g., by a computer), leading to sensory attenuation, i.e., a reduction in perceived loudness or brain evoked ...
Liyu eCao, Joachim eGross
doaj +1 more source