Results 81 to 90 of about 802,446 (258)

Deep generative models in the quest for anticancer drugs: ways forward

Frontiers in Drug Discovery
Drug discovery is a costly and time-consuming process, especially because of the significant expenses connected with the high percentage of clinical trial failures.
Virgilio Romanelli, Carmen Cerchia, Antonio Lavecchia   +2 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Reply to 'Forward models of repetition suppression depend critically on assumptions of noise and granularity'. [PDF]

Nat Commun, 2020
Alink A, Abdulrahman H, Henson RN.
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Two dynamical models for male infertility and their stability and sensitivity analysis

Scientific Reports
Mathematical models can estimate the success rate of assisted reproductive technology (ART) and determine which treatment suits the best. In this study, the authors introduce two new dynamic models that can predict the success rate of ART models for each
Somaye Ghiasi Hafezi, Mahdi Ranjbar, Atena Ghasemabadi, Sohrab Effati, Alvand Naserghandi, Kosar Namakin, Farzad Allameh   +6 more
doaj   +1 more source

Forward models of repetition suppression depend critically on assumptions of noise and granularity. [PDF]

Nat Commun, 2020
Ramírez FM, Merriam EP.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

The path forward for large language models in medicine is open

npj Digital Medicine
Large language models (LLMs) are increasingly applied in medical documentation and have been proposed for clinical decision support. We argue that the future for LLMs in medicine must be based on transparent and controllable open-source models.
Lars Riedemann, Maxime Labonne, Stephen Gilbert   +2 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source