Results 101 to 110 of about 3,277,460 (290)
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Reply to 'Forward models of repetition suppression depend critically on assumptions of noise and granularity'. [PDF]
Nat Commun, 2020 Alink A, Abdulrahman H, Henson RN.
europepmc +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Two dynamical models for male infertility and their stability and sensitivity analysis
Scientific ReportsMathematical models can estimate the success rate of assisted reproductive technology (ART) and determine which treatment suits the best. In this study, the authors introduce two new dynamic models that can predict the success rate of ART models for each
Somaye Ghiasi Hafezi +6 more
doaj +1 more source
Forward models of repetition suppression depend critically on assumptions of noise and granularity. [PDF]
Nat Commun, 2020 Ramírez FM, Merriam EP.
europepmc +1 more source
Revisiting the predictability of bond risk premia [PDF]
This paper investigates the source of predictability of bond risk premia by means of long-term forward interest rates. We show that the predictive ability of forward rates could be due to the high serial correlation and cross-correlation of bond prices ...
Daniel L. Thornton, Giorgio Valente
core
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Mean-Reverting Stochastic Processes, Evaluation of Forward Prices and Interest Rates [PDF]
We consider mean-reverting stochastic processes and build self-consistent models for forward price dynamics and some applications in power industries. These models are built using the ideas and equations of stochastic differential geometry in order to ...
Aguero-Granados, M. A., Makhankov, V. G.
core +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
The path forward for large language models in medicine is open
npj Digital MedicineLarge language models (LLMs) are increasingly applied in medical documentation and have been proposed for clinical decision support. We argue that the future for LLMs in medicine must be based on transparent and controllable open-source models.
Lars Riedemann +2 more
doaj +1 more source