Results 31 to 40 of about 1,018 (260)
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
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P. Gardner, LANEVE, COSIMO, L. Wischik
openaire +2 more sources
Sleep Deprivation in the Forward-Forward Algorithm
This paper aims to explore the separation of the two forward passes in the Forward-Forward algorithm from a biological perspective in the context of sleep. We show the size of the gap between the sleep and awake phase influences the learning capabilities of the algorithm and highlight the importance of negative data in diminishing the devastating ...
Mircea Tudor Lica, David Dinucu-Jianu
openaire +3 more sources
Applicability of hydraulic dynamometer for measuring load mass on forwarders [PDF]
In the last few years, with the start of wood biomass production from wood residues, the need for determining the quantity of extracted wood residuals on a landing site has appeared.
Pandur Zdravko +5 more
doaj +1 more source
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Fuel Consumption of Forwarders in Lowland Forests of Pedunculate Oak
Background and Purpose: Fuel consumption in timber harvesting operations is significant for both economic and environmental reasons. In economic sense, one significant part of timber harvesting costs is reduced to fuel costs, and in environmental sense ...
Zdravko Pandur +5 more
doaj +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
On Advancements of the Forward-Forward Algorithm [PDF]
The Forward-Forward algorithm has evolved in machine learning research, tackling more complex tasks that mimic real-life applications. In the last years, it has been improved by several techniques to perform better than its original version, handling a challenging dataset like CIFAR10 without losing its flexibility and low memory usage.
Ortiz Torres, Mauricio +2 more
openaire +5 more sources

