Results 51 to 60 of about 1,018 (260)
Revista Árvore, 2005 A qualidade das operações foi avaliada em cinco subsistemas de colheita, adotados por empresas florestais brasileiras que utilizam madeira para produção de celulose de fibras curtas e painéis.
Laércio Antônio Gonçalves Jacovine +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
CoRR, 2023 The backpropagation algorithm, despite its widespread use in neural network learning, may not accurately emulate the human cortex's learning process. Alternative strategies, such as the Forward-Forward Algorithm (FFA), offer a closer match to the human cortex's learning characteristics.
openaire +2 more sources
Ecoefficient Timber Forwarding Based on Nominal Ground Pressure Analysis
Croatian Journal of Forest Engineering, 2011 This paper presents the research of possibilities of forwarding timber in an efficient and environmentally friendly way, under conditions of limited bearing capacity of gley soils of Croatian lowland forests due to their increased moisture all the year ...
Tomislav Poršinsky +2 more
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Application of harvester technologies of timber logging in the process-oriented environment
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2009 Harvester technologies of timber logging currently represent the high spot of technologies used in forestry for timber harvesting and forwarding. A typical feature of the “harvester– forwarder” combination is production rate, which is many times higher ...
Pavel Máchal, Luboš Bartoš
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source